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المؤلفAli-Adib, Sandi
المؤلفAbuhelwa, Ahmad
المؤلفYounes, Husam M
تاريخ الإتاحة2022-03-10T06:31:19Z
تاريخ النشر2012
اسم المنشورQatar Foundation Annual Research Forum Proceedings
المصدرqscience
الاقتباسAli-Adib, Sandi, Abuhelwa, Ahmad, Younes, Husam M. (2012). Novel oral formulations of metformin in semi-solid matrices: Design, characterization and in vitro dissolution testing. Qatar Foundation Annual Research Forum Proceedings 2012: BMP47 https://doi.org/10.5339/qfarf.2012.BMP47
الرقم المعياري الدولي للكتاب2226-9649
معرّف المصادر الموحدhttps://doi.org/10.5339/qfarf.2012.BMP47
معرّف المصادر الموحدhttp://hdl.handle.net/10576/27951
الملخصObjectives: To formulate and evaluate oral dosage forms of metformin hydrochloride (MH) having sustained-release properties that would also increase MH bioavailability and address the shortcomings in the currently marketed sustained-release tablets. Methods: MH micronized powder was dispersed in molten polymeric matrices composed of Gelucire 50/13 and various proportions of high molecular weight hydrophilic polymers, hydrophobic oily semisolid excipients, and mucoadhesive polymeric materials. The MH loaded matrices were filled in hard gelatin capsules (HGC) each containing 500 mg MH and were subsequently characterized using differential scanning calorimetry (DSC) and X-ray diffraction (XRD) analysis. The prepared HGC were subjected to content uniformity and in vitro dissolution testing according to the USP-35 compendium requirements. The dissolution data were compared to instant and sustained-release marketed tablets. The effect of incorporating various proportions of the semisolid excipients on MH dissolution release rate, were also investigated. Results: MH content of the prepared HGC ranged between 96 to 103%. All the prepared semisolid filled HGC resulted in extended-release profiles of MH that lasted between 5 to 11 hours and demonstrated a release pattern which typically follows the release from mixes of triglycerides with polyethylene glycol esters of fatty acids. The incorporation of mucoadhesive excipients like carbomer to the Gelucire 50/13-MH semisolid matrices extended the release of MH from 5 hours initially to 9 hours as a result of the formation of a gel layer around the matrix. However, the incorporation of different hydrophilic excipients like PEG35000 and Gelucire 44/14 along with the mucoadhesive excipients sustained the release of MH up to 11 hours. XRD analysis of the MH prepared matrices demonstrated minor changes in the crystalline nature of MH. Depending on the loading ratios and the nature of the semisolid matrices used, DSC analysis revealed the changes in MH crystallinity to be from 100 to 23%. Conclusion: HGC formulated using semisolid matrices showed promising results in extending the release of MH. However, bioavailability studies to test the ability of such Gelucire based HGC of MH to improve its bioavailability and in vivo residence times are future plans.
اللغةen
الناشرHamad bin Khalifa University Press (HBKU Press)
الموضوعmetformin
semi-solid matrices
metformin hydrochloride (MH)
ard gelatin capsules (HGC)
العنوانNovel oral formulations of metformin in semi-solid matrices: Design, characterization and in vitro dissolution testing
النوعConference Paper
رقم العدد1
رقم المجلد2012
dc.accessType Open Access


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