Show simple item record

AuthorMeskin, Nader
AuthorNounou, H.
AuthorNounou, M.
AuthorDatta, A.
AuthorDougherty, E.R.
Available date2022-04-14T08:45:47Z
Publication Date2011
Publication NameProceedings of the American Control Conference
ResourceScopus
Identifierhttp://dx.doi.org/10.1109/acc.2011.5990875
URIhttp://hdl.handle.net/10576/29840
AbstractRecent years have witnessed extensive research activity in modeling genetic regulatory networks (GRNs) as well as in developing therapeutic intervention strategies for such networks. S-systems, which offer a good compromise between accuracy and mathematical flexibility, are a promising framework for modeling the dynamical behavior of GRNs, as well as that of biochemical pathways. In this paper, an intervention strategy is proposed for the S-system model. In this approach, a model predictive control algorithm is developed which guides the target variables to their desired values. The proposed intervention strategy is applied to the glycolytic-glycogenolytic pathway as well as a generic branched pathway and the simulation results presented demonstrate the effectiveness of the proposed scheme. 2011 AACC American Automatic Control Council.
Languageen
PublisherInstitute of Electrical and Electronics Engineers Inc.
SubjectPredictive control systems
Biochemical pathway
Biological phenomena
Dynamical behaviors
Genetic regulatory networks
Intervention strategy
Model-predictive control approach
Research activities
Therapeutic intervention
Model predictive control
TitleIntervention in biological phenomena modeled by S-systems: A model predictive control approach
TypeConference Paper
Pagination3519-3523
dc.accessType Abstract Only


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record