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    Aquaporins Are One of the Critical Factors in the Disruption of the Skin Barrier in Inflammatory Skin Diseases

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    Date
    2022-04-01
    Author
    Tricarico, Paola Maura
    Mentino, Donatella
    De Marco, Aurora
    Del Vecchio, Cecilia
    Garra, Sabino
    Cazzato, Gerardo
    Foti, Caterina
    Crovella, Sergio
    Calamita, Giuseppe
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    Abstract
    The skin is the largest organ of the human body, serving as an effective mechanical barrier between the internal milieu and the external environment. The skin is widely considered the first-line defence of the body, with an essential function in rejecting pathogens and preventing mechanical, chemical, and physical damages. Keratinocytes are the predominant cells of the outer skin layer, the epidermis, which acts as a mechanical and water-permeability barrier. The epidermis is a permanently renewed tissue where undifferentiated keratinocytes located at the basal layer proliferate and migrate to the overlying layers. During this migration process, keratinocytes undertake a differentiation program known as keratinization process. Dysregulation of this differentiation process can result in a series of skin disorders. In this context, aquaporins (AQPs), a family of membrane channel proteins allowing the movement of water and small neutral solutes, are emerging as important players in skin physiology and skin diseases. Here, we review the role of AQPs in skin keratinization, hydration, keratinocytes proliferation, water retention, barrier repair, wound healing, and immune response activation. We also discuss the dysregulated involvement of AQPs in some common inflammatory dermatological diseases characterised by skin barrier disruption.
    URI
    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85127563768&origin=inward
    DOI/handle
    http://dx.doi.org/10.3390/ijms23074020
    http://hdl.handle.net/10576/30029
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    • Biological & Environmental Sciences [‎931‎ items ]

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