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المؤلفSalman, Huseyin Enes
المؤلفKamal, Reema Yousef
المؤلفHijazi, Ziyad M.
المؤلفYalcin, Huseyin Cagatay
تاريخ الإتاحة2022-04-24T08:10:02Z
تاريخ النشر2022-03-23
اسم المنشورFrontiers in Physiology
المعرّفhttp://dx.doi.org/10.3389/fphys.2022.856879
الاقتباسSalman HE, Kamal RY, Hijazi ZM and Yalcin HC (2022) Hemodynamic and Structural Comparison of Human Fetal Heart Development Between Normally Growing and Hypoplastic Left Heart Syndrome-Diagnosed Hearts. Front. Physiol. 13:856879. doi: 10.3389/fphys.2022.856879
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85128211066&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/30245
الملخصCongenital heart defects (CHDs) affect a wide range of societies with an incidence rate of 1.0–1.2%. These defects initiate at the early developmental stage and result in critical health disorders. Although genetic factors play a role in the formation of CHDs, the occurrence of cases in families with no history of CHDs suggests that mechanobiological forces may also play a role in the initiation and progression of CHDs. Hypoplastic left heart syndrome (HLHS) is a critical CHD, which is responsible for 25–40% of all prenatal cardiac deaths. The comparison of healthy and HLHS hearts helps in understanding the main hemodynamic differences related to HLHS. Echocardiography is the most common imaging modality utilized for fetal cardiac assessment. In this study, we utilized echocardiographic images to compare healthy and HLHS human fetal hearts for determining the differences in terms of heart chamber dimensions, valvular flow rates, and hemodynamics. The cross-sectional areas of chamber dimensions are determined from 2D b-mode ultrasound images. Valvular flow rates are measured via Doppler echocardiography, and hemodynamic quantifications are performed with the use of computational fluid dynamics (CFD) simulations. The obtained results indicate that cross-sectional areas of the left and right sides of the heart are similar for healthy fetuses during gestational development. The left side of HLHS heart is underdeveloped, and as a result, the hemodynamic parameters such as flow velocity, pressure, and wall shear stress (WSS) are significantly altered compared to those of healthy hearts.
راعي المشروعThis study was funded by the Qatar National Research Fund (QNRF), National Priority Research Program (NPRP 10-0123-170222). Open access funding was provided by the Qatar National Library.
اللغةen
الناشرFrontiers Media
الموضوعcomputational fluid dynamics
congenital heart defects
disturbed hemodynamics
echocardiography
fetal heart development
hypoplastic left heart syndrome
mitral valve
tricuspid valve
العنوانHemodynamic and Structural Comparison of Human Fetal Heart Development Between Normally Growing and Hypoplastic Left Heart Syndrome-Diagnosed Hearts
النوعArticle
رقم المجلد13
ESSN1664-042X
dc.accessType Open Access


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