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Now showing items 41-49 of 49
STANDARDIZATION OF AN IN VITRO MODEL OF DIABETIC NEPHROPATHY IN RENAL TUBULAR CELLS AND INVESTIGATION OF THE ROLE OF ALDOSE REDUCTASE PATHWAY IN HIGH GLUCOSE-INDUCED RENAL CELL INJURY
(Pharmacy, 2015 , Master Thesis)
Diabetic nephropathy (DN) is the leading cause of end stage renal disease, and one of the most serious microvascular complications of diabetes mellitus. Increase in the shift of glucose into the aldose reductase pathway ...
Synthesis and Pharmacological Evaluation of Different Piperine Analogs for Therapeutic Potential to Prevent ER Stress
(Pharmacy, 2015 , Master Thesis)
Background: Endoplasmic reticulum (ER) is the chief organelle involved in protein folding and maturation. Emerging studies implicate the role of ER stress in the development of chronic kidney disease (CKD). Thus, there is ...
Anticancer Activity of Neosetophomone-B, a Fungal Secondary Metabolite, Against Hematological Malignancies
(Pharmacy, 2023 , Dissertation)
Anticancer Activity of Neosetophomone-B, a Fungal Secondary Metabolite, Against Hematological Malignancies downregulation, and p21 and p27 upregulation were observed in NSP-B-treated leukemia, lymphoma, and myeloma cells. ...
Trends and Appropriateness of Sodium-glucose Co-transporter 2 Inhibitors Use in Qatar
(Pharmacy, 2023 , Master Thesis)
Background: Sodium glucose co-transporter 2 inhibitors (SGLT2is) are the most
recently approved class of oral antidiabetic drugs (ADDs). The objective of this study
was to explore the trends in the use of SGLT2is compared ...
DRUG SURVIVAL OF DIFFERENT BIOLOGICS IN PSORIATIC PATIENTS - EVIDENCE SYNTHESIS AND HISTORICAL COHORT STUDY
(Pharmacy, 2023 , Master Thesis)
Biologic therapies have revolutionized the treatment of psoriasis, providing high levels of efficacy and safety. However, the choice of the appropriate therapy for each patient remains a challenge. The primary objective ...
Ethanol-Based Proliposomes Incorporating Dexamethasone for The Treatment of COVID-19 Acute Respiratory Distress Syndrome (ARDS) Using Medical Nebulizers
(Pharmacy, 2023 , Master Thesis)
Background/Objective: Systemic dexamethasone has demonstrated mortality
reduction in COVID-19-related acute respiratory distress syndrome (ARDS). The aim
of this study is to use ethanol-based proliposome technology to ...
Developing Pharmacist-Led Anticoagulation Clinics in Primary Care Settings: A Multi-Phase Mixed-Methods Study
(Pharmacy, 2024 , Master Thesis)
Background: Primary care is an integral part of the healthcare system. Patients have better accessibility and continuity of care. However, studies have reported low-quality warfarin management in these settings. Pharmacist-led ...
Nano Liposomal Formulation for A Novel Chalcone Compound as A Potential Anticancer Delivery System for Triple-Negative Breast Cancer
(Pharmacy, 2024 , Master Thesis)
Triple negative breast cancer is the most aggressive type of breast malignancy accounting for 15-20% of all breast cancer cases. Treatment of TNBC remains limited, with a high risk of relapse and metastasis to other organs. ...
The Cytotoxicity Of “Al-Siddir” Tree “Ziziphus Spina Christi” Methanolic Leaves Extract on Her-2 Positive Breast Cancer
(Pharmacy, 2024 , Master Thesis)
HER-2 positive is a subtype of breast cancer that acquires poor prognosis and low survival rates. Targeted therapy is one of the main approaches that are used for the treatment of HER-2-positive breast cancer. However, it ...