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المؤلفSiebert, Leonard
المؤلفLuna-Cerón, Eder
المؤلفGarcía-Rivera, Luis Enrique
المؤلفOh, Junsung
المؤلفJang, JunHwee
المؤلفRosas-Gómez, Diego A.
المؤلفPérez-Gómez, Mitzi D.
المؤلفMaschkowitz, Gregor
المؤلفFickenscher, Helmut
المؤلفOceguera-Cuevas, Daniela
المؤلفHolguín-León, Carmen G.
المؤلفByambaa, Batzaya
المؤلفHussain, Mohammad A.
المؤلفEnciso-Martínez, Eduardo
المؤلفCho, Minsung
المؤلفLee, Yuhan
المؤلفSobahi, Nebras
المؤلفHasan, Anwarul
المؤلفOrgill, Dennis P.
المؤلفMishra, Yogendra Kumar
المؤلفAdelung, Rainer
المؤلفLee, Eunjung
المؤلفShin, Su Ryon
تاريخ الإتاحة2022-05-21T10:18:27Z
تاريخ النشر2021
اسم المنشورAdvanced Functional Materials
المصدرScopus
المعرّفhttp://dx.doi.org/10.1002/adfm.202007555
معرّف المصادر الموحدhttp://hdl.handle.net/10576/31273
معرّف المصادر الموحدhttp://dx.doi.org/10.1002/adfm.202007555
الملخصAdvanced wound scaffolds that integrate active substances to treat chronic wounds have gained significant recent attention. While wound scaffolds and advanced functionalities have previously been incorporated into one medical device, the wirelessly triggered release of active substances has remained the focus of many research endeavors. To combine multiple functions including light-triggered activation, antiseptic, angiogenic, and moisturizing properties, a 3D printed hydrogel patch encapsulating vascular endothelial growth factor (VEGF) decorated with photoactive and antibacterial tetrapodal zinc oxide (t-ZnO) microparticles is developed. To achieve the smart release of VEGF, t-ZnO is modified by chemical treatment and activated through ultraviolet/visible light exposure. This process would also make the surface rough and improve protein adhesion. The elastic modulus and degradation behavior of the composite hydrogels, which must match the wound healing process, are adjusted by changing t-ZnO concentrations. The t-ZnO-laden composite hydrogels can be printed with any desired micropattern to potentially create a modular elution of various growth factors. The VEGF-decorated t-ZnO-laden hydrogel patches show low cytotoxicity and improved angiogenic properties while maintaining antibacterial functions in vitro. In vivo tests show promising results for the printed wound patches, with less immunogenicity and enhanced wound healing.
اللغةen
الناشرJohn Wiley and Sons Inc
الموضوع3D printing
controlled release
hydrogel composites
photoactive
wound healing
zinc oxide tetrapod
العنوانLight-Controlled Growth Factors Release on Tetrapodal ZnO-Incorporated 3D-Printed Hydrogels for Developing Smart Wound Scaffold
النوعArticle
الصفحات153-170
رقم العدد22
رقم المجلد31


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