Light-Controlled Growth Factors Release on Tetrapodal ZnO-Incorporated 3D-Printed Hydrogels for Developing Smart Wound Scaffold
Date
2021Author
Siebert, LeonardLuna-Cerón, Eder
García-Rivera, Luis Enrique
Oh, Junsung
Jang, JunHwee
Rosas-Gómez, Diego A.
Pérez-Gómez, Mitzi D.
Maschkowitz, Gregor
Fickenscher, Helmut
Oceguera-Cuevas, Daniela
Holguín-León, Carmen G.
Byambaa, Batzaya
Hussain, Mohammad A.
Enciso-Martínez, Eduardo
Cho, Minsung
Lee, Yuhan
Sobahi, Nebras
Hasan, Anwarul
Orgill, Dennis P.
Mishra, Yogendra Kumar
Adelung, Rainer
Lee, Eunjung
Shin, Su Ryon
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Metadata
Show full item recordAbstract
Advanced wound scaffolds that integrate active substances to treat chronic wounds have gained significant recent attention. While wound scaffolds and advanced functionalities have previously been incorporated into one medical device, the wirelessly triggered release of active substances has remained the focus of many research endeavors. To combine multiple functions including light-triggered activation, antiseptic, angiogenic, and moisturizing properties, a 3D printed hydrogel patch encapsulating vascular endothelial growth factor (VEGF) decorated with photoactive and antibacterial tetrapodal zinc oxide (t-ZnO) microparticles is developed. To achieve the smart release of VEGF, t-ZnO is modified by chemical treatment and activated through ultraviolet/visible light exposure. This process would also make the surface rough and improve protein adhesion. The elastic modulus and degradation behavior of the composite hydrogels, which must match the wound healing process, are adjusted by changing t-ZnO concentrations. The t-ZnO-laden composite hydrogels can be printed with any desired micropattern to potentially create a modular elution of various growth factors. The VEGF-decorated t-ZnO-laden hydrogel patches show low cytotoxicity and improved angiogenic properties while maintaining antibacterial functions in vitro. In vivo tests show promising results for the printed wound patches, with less immunogenicity and enhanced wound healing.
DOI/handle
http://dx.doi.org/10.1002/adfm.202007555http://hdl.handle.net/10576/31273
http://dx.doi.org/10.1002/adfm.202007555
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- Mechanical & Industrial Engineering [1342 items ]