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AuthorAtta, Nada F.
AuthorElzatahry, Ahmed
AuthorAbdo, Ghada G.
AuthorHassan, Samar H.
Available date2022-05-22T09:12:23Z
Publication Date2021
Publication NameCanadian Journal of Chemistry
ResourceScopus
Identifierhttp://dx.doi.org/10.1139/cjc-2020-0199
URIhttp://hdl.handle.net/10576/31355
AbstractA novel composite for the electrochemical sensing of tramadol (Tr) was developed by the inclusion of a metallocene mediator between two layers of conducting poly(3,4-ethylenedioxythiophene) (PEDOT) polymer, in the presence of sodium dodecyl sulfate (SDS), i.e., P/mediator/P. . .SDS. Three charge transfer mediators were evaluated: ferrocene carboxylic acid (FC1), ferrocene (FC2), and cobaltocene (CC) for Tr electrocatalytic oxidation. The FC1 charge mediator showed a relatively higher current response that was assisted by the electronic conduction of the polymer film. Moreover, SDS presented a great impact, resulting in the enhancement of the preconcentration and (or) accumulation of Tr ions at the interface, leading to faster electron transfer. In addition, the practical application of the proposed FC1 composite for the determination of Tr in real urine and serum samples was successfully achieved with adequate recovery results. Very low detection limits of 18.6 nM and 16 nM in the linear dynamic ranges of 7?300 ?M and 5?280 ?M, respectively, were obtained at the proposed sensor. Furthermore, the simultaneous determination of Tr with common interfering species, paracetamol (APAP), morphine (MO), dopamine (DA), ascorbic acid (AA) and uric acid (UA), proved excellent, with good resolution and large potential peaks separation. The excellent characteristics of the proposed composite such as high reproducibility, good sensitivity, selectivity, anti-interference ability, and good stability enhanced its application for determination of other narcotic drugs.
Languageen
PublisherCanadian Science Publishing
SubjectAmines
Ascorbic acid
Charge transfer
Conducting polymers
Electrocatalysis
Electron transport properties
Iron compounds
Organometallics
Polymer films
Semiconducting films
Sodium dodecyl sulfate
Sulfur compounds
Charge-transfer mediator
Conducting polymer composites
Electro-catalytic oxidation
Electrochemical sensing
Electronic conduction
Linear dynamic ranges
Poly(3 ,4 ethylenedioxythiophene) (PEDOT)
Simultaneous determinations
Electrochemical sensors
TitleDesigned electrochemical sensor based on metallocene modified conducting polymer composite for effective determination of tramadol in real samples
TypeArticle
Pagination437-446
Issue Number5
Volume Number99
dc.accessType Abstract Only


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