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Vitamin D Immune Modulatory Effect on the Anti-inflammatory potential of HDL Associated Proteins
(Medical Sciences, 2023 , Dissertation)
Introduction: Vitamin D deficiency is highly prevalent in Qatar. Vitamin D exerts immune-modulatory effects leading to reduced inflammation. Therefore, vitamin D deficiency is associated with increased subclinical inflammation. ...
INVESTIGATING THE MOLECULAR MECHANISMS OF SHEAR STRESS INDUCED ENDOTHELIAL DYSFUNCTION AND PROGRESSION OF ATHEROSCLEROSIS
(Medical Sciences, 2024 , Dissertation)
Background: Atherosclerotic vascular disease, such as coronary artery disease (CAD) and ischemic stroke is the leading cause of mortality and disability worldwide. Therefore, understanding the mechanisms underlying ...
VASCULAR REMODELING IN HYPERTENSION: IN-VITRO/ EX-VIVO MECHANICAL STRETCH-INDUCED ALTERATIONS AND OMICS ANALYSIS
(Medical Sciences, 2024 , Dissertation)
Hypertension, being a primary vasculature disorder, contributes significantly to premature death globally. Over the years, numerical figures have evidenced a dramatic increase in hypertension’s global prevalence, affecting ...
DEVELOPMENT OF A PROBLEM AND ATTRIBUTES BASED DIABETES SELF-MANAGEMENT (PARADIGM) INTERVENTION
(Medical Sciences, 2022 , Dissertation)
Background: Type 2 diabetes mellitus (T2D), is a growing pandemic across the world. T2D requires a comprehensive diabetes self-management (DSM) skills in addition to medications. It is still unclear what interventions can ...
Co-Presence and Cooperation of High-Risk Human Papillomaviruses and Epstein-Barr Virus in Colorectal Cancer
(Medicine, 2024 , Dissertation)
The Human Papillomavirus (HPV) and Epstein-Barr Virus (EBV) are potent oncoviruses involved in the pathogenesis of various cancers like colorectal cancer. Further the cooperation between high risk (HR) types of HPV as well ...
STRUCTURAL AND FUNCTIONAL APPROACHES TOWARD ACTIVITY RESTORATION OF NOVEL CYSTATHIONINE BETA-SYNTHASE MUTATIONS
(Medical Sciences, 2024 , Dissertation)
Homocystinuria, a rare disorder stemming from mutations in the CBS gene, results in cystathionine β-synthase (CBS) deficiency. CBS is a pivotal enzyme whose activity is enhanced by the allosteric regulator S-adenosylmethionine ...
METABOLIC CHANGES AFTER SURGICAL SUBCUTANEOUS FAT REMOVAL
(Clinical Sciences, 2023 , Dissertation)
Background: There is increasing demand for both surgical (SSFR) and nonsurgical (NSSFR) subcutaneous fat removal procedures for achieving immediate improvements in physical appearance. However, their metabolic effects ...