• English
    • العربية
  • العربية
  • Login
  • QU
  • QU Library
  •  Home
  • Communities & Collections
  • Help
    • Item Submission
    • Publisher policies
    • User guides
    • FAQs
  • About QSpace
    • Vision & Mission
View Item 
  •   Qatar University Digital Hub
  • Qatar University Institutional Repository
  • Academic
  • Faculty Contributions
  • College of Arts & Sciences
  • Biological & Environmental Sciences
  • View Item
  • Qatar University Digital Hub
  • Qatar University Institutional Repository
  • Academic
  • Faculty Contributions
  • College of Arts & Sciences
  • Biological & Environmental Sciences
  • View Item
  •      
  •  
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Differential distribution of vitamin D receptor (VDR) gene variants and its expression in systemic lupus erythematosus

    View/Open
    VDR Systemic Lupus Erythematosus (721.1Kb)
    Date
    2022-01-01
    Author
    De Azevêdo Silva, Jaqueline
    de Lima, Suelen Cristina
    Fragoso, Thiago Sotero
    Cavalcanti, Catarina Addobbati Jordão
    Barbosa, Alexandre Domingues
    Borborema, Maria Eduarda de Albuquerque
    de Lucena, Thays Maria Costa
    Duarte, Angela Luzia Branco Pinto
    Crovella, Sergio
    Sandrin-Garcia, Paula
    ...show more authors ...show less authors
    Metadata
    Show full item record
    Abstract
    Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder that displays an important genetic background. Vitamin D3 (VD3) through its receptor (VDR) plays an important immunomodulatory role in autoimmune misbalance, being capable of modulating immune responses. Genetic alterations in VDR gene may contribute to an altered risk in SLE development and clinical manifestations. We investigated VDR SNPs (single nucleotide polymorphisms) frequencies in 128 SLE patients and 138 healthy controls (HC) and mRNA differential expression in 29 patients and 17 HC regarding SLE susceptibility as well as clinical features. We observed that rs11168268 G allele (OR = 1.55, p =.01) and G/G genotype (OR = 2.69, p =.008) were associated with increased SLE susceptibility. The rs2248098 G allele and A/G and G/G genotypes were associated to lower SLE susceptibility (OR = 0.66, p =.01; OR = 0.46, p =.01; OR = 0.44, p =.02, respectively). Regarding clinical features, we observed lower risk for: rs11168268 A/G genotype and nephritis (OR = 0.31, p =.01); rs4760648 T/T genotype and photosensitivity (OR = 0.24, p =.02); rs1540339 T/T genotype and antibody anti-dsDNA (OR = 0.19, p =.015); rs3890733 T/T genotype and serositis (OR = 0.10, p =.01). We identified a significant downregulation in VDR expression levels when compared patients and controls overall (p = 1.04e–7), in Cdx-2 A/G and G/G (p =.008 and p =.014, respectively) and in patients with nephritis (p =.016). Our results suggested that VDR SNPs influence upon SLE susceptibility and in particular clinical features, acting on mRNA expression in SLE patients overall and the ones with nephritis.
    URI
    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85129881280&origin=inward
    DOI/handle
    http://dx.doi.org/10.1111/iji.12576
    http://hdl.handle.net/10576/31705
    Collections
    • Biological & Environmental Sciences [‎933‎ items ]

    entitlement


    Qatar University Digital Hub is a digital collection operated and maintained by the Qatar University Library and supported by the ITS department

    Contact Us | Send Feedback
    Contact Us | Send Feedback | QU

     

     

    Home

    Submit your QU affiliated work

    Browse

    All of Digital Hub
      Communities & Collections Publication Date Author Title Subject Type Language Publisher
    This Collection
      Publication Date Author Title Subject Type Language Publisher

    My Account

    Login

    Statistics

    View Usage Statistics

    About QSpace

    Vision & Mission

    Help

    Item Submission Publisher policiesUser guides FAQs

    Qatar University Digital Hub is a digital collection operated and maintained by the Qatar University Library and supported by the ITS department

    Contact Us | Send Feedback
    Contact Us | Send Feedback | QU

     

     

    Video