تصفح Faculty Contributions حسب العنوان
السجلات المعروضة 8964 -- 8983 من 18423
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In vitro and in vivo efficacy of a novel quinuclidinone derivative against breast cancer
( International Institute of Anticancer Research , 2014 , Other)Previously, our laboratory reported on novel quinuclidinone derivatives that cause cytotoxicity in human non-small lung carcinoma epithelial cells null for p53 (H1299). The current study aims to investigate the effect of ... -
In vitro and in vivo inhibition of aldose reductase and advanced glycation end products by phloretin, epigallocatechin 3-gallate and [6]-gingerol
( Elsevier , 2016 , Article)Abstract Hyperglycemic stress activates polyol pathway and aldose reductase (AR) key enzyme responsible for generating secondary complications during diabetes. In this study the therapeutic potential of phloretin, ... -
In Vitro and In Vivo Validation of GATA-3 Suppression for Induction of Adipogenesis and Improving Insulin Sensitivity
( MDPI , 2022 , Article)Impaired adipogenesis is associated with the development of insulin resistance and an increased risk of type 2 diabetes (T2D). GATA Binding Protein 3 (GATA3) is implicated in impaired adipogenesis and the onset of insulin ... -
In vitro effects of hydrogen peroxide on rat uterine contraction before and during pregnancy
( Medicinska Naklada Zagreb , 2018 , Article)Aim To assess the in vitro effect of hydrogen peroxide (H 2 O 2 ) on uterine contractions in pregnant and non-pregnant rats. Methods The study was performed at the Department of Physiology, College of Medicine, King Saud ... -
In vitro effects of photobiomodulation therapy on 50B11 sensory neurons: evaluation of cell metabolism, oxidative stress, mitochondrial membrane potential (MMP), and capsaicin-induced calcium flow
( Wiley , 2021 , Article)The analgesic properties of photobiomodulation therapy (PBMT) have been raising increasing interest in the clinical community due to the positive effects observed on patients, nevertheless the mechanistic basis of its ... -
In vitro evaluation of Neosetophomone B inducing apoptosis in cutaneous T cell lymphoma by targeting the FOXM1 signaling pathway
( Elsevier , 2023 , Article)Background: Cutaneous T cell lymphoma (CTCL) is a T cell-derived non-Hodgkin lymphoma primarily affecting the skin, with treatment posing a significant challenge and low survival rates. Objective: In this study, we ... -
In vitro models and systems for evaluating the dynamics of drug delivery to the healthy and diseased brain
( Elsevier B.V. , 2018 , Article Review)The blood-brain barrier (BBB) plays a crucial role in maintaining brain homeostasis and transport of drugs to the brain. The conventional animal and Transwell BBB models along with emerging microfluidic-based BBB-on-chip ... -
In vitro Synthesis, Structure Elucidation, and Antioxidant Properties of Platinum(IV)-hydrazide Complexes: Molecular Modeling of Free-Hydrazides Suggested as Potent Lipoxygenase Inhibitor
( Bentham Science Publishers , 2022 , Article)Background: A combination of biologically active ligand and metal in one molecule may increase the activity and reduce the toxicity. Objectives: In this study, the synthesis and characterization of platinum(IV) complexes ... -
In vitrocomparison of natural tooth-whitening remedies and professional tooth-whitening systems
( Elsevier , 2023 , Article)BackgroundAn increasing number of patients are using natural homemade remedies such as strawberries, banana peels, coconut oil rinse, basil, lemon, activated charcoal, apple cider vinegar, baking soda, and turmeric to ... -
In vivo and in vitro studies evaluating the chemopreventive effect of metformin on the aryl hydrocarbon receptor-mediated breast carcinogenesis
( Elsevier , 2021 , Article)Metformin (MET) is a clinically used anti-hyperglycemic agent that shows activities against chemically-induced animal models of cancer. A study from our laboratory showed that MET protectes against 7, 12-dimethylbenz[a]anthracene ... -
In Vivo Evaluation of Taste-Masked Fast-Disintegrating Sublingual Tablets of Epinephrine Microcrystals
( Springer New York LLC , 2018 , Article)n community settings, IM injection of 0.3 mg epinephrine (Epi) using an auto-injector is the drug of choice for treatment of anaphylaxis. Previously, a taste-masking (TM) formulation of fast-disintegrating sublingual tablets ... -
In vivo testing of novel nitric oxide-releasing nanoparticles for alleviating heart failure using the zebrafish embryo model
( Elsevier , 2024 , Article)Heart failure (HF) is a multifactorial, heterogeneous systemic disease that is considered one of the leading causes of death and morbidity worldwide. It is well-known that endothelial dysfunction (ED) plays an important ... -
In-depth Analysis of Pedestrian Safety in the State of Qatar
( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference Paper)Pedestrian safety is of a serious concern as it includes children and the aged population. From the Global status report on road safety in 2015 by World Health Organization (WHO), it can be seen that pedestrian fatalities ... -
In-formalized polity and the politics of dynasty in Egypt and Libya
( Taylor and Francis , 2014 , Book chapter)The Arab Middle East has entered a moment of revolution, inevitable counterrevolution, and transition. Integral to this moment is a dialectical dynamic in which the formal and the informal conjugate, through unsettled ... -
In-frame fusion of SUMO1 enhances βarrestin2's association with activated GPCRs as well as with nuclear pore complexes
( Elsevier , 2020 , Article)Small ubiquitin like modifier (SUMO) conjugation or SUMOylation of βarrestin2 promotes its association with the clathrin adaptor protein AP2 and facilitates rapid β2 adrenergic receptor (β2AR) internalization. However, ... -
In-memory distributed matrix computation processing & optimization
( IEEE Computer Society , 2017 , Conference Paper)The use of large-scale machine learning and data mining methods is becoming ubiquitous in many application domains ranging from business intelligence and bioinformatics to self-driving cars. These methods heavily rely on ... -
In-network data reduction approach based on smart sensing
( Institute of Electrical and Electronics Engineers Inc. , 2016 , Conference Paper)The rapid advances in wireless communication and sensor technologies facilitate the development of viable mobile-Health applications that boost opportunity for ubiquitous real- time healthcare monitoring without constraining ... -
In-plane stress analysis of multiple parallel cracks in an orthotropic FGM medium under time-harmonic loading
( Elsevier , 2021 , Article)This study aimed to investigate the fracture behavior of a cracked orthotropic FGM medium when exposed to an in-plane harmonic load. The mechanical feature of the medium exponentially varied along the y-axis. Using the ... -
In-season weightlifting training exercise in healthy male handball players: Effects on body composition, muscle volume, maximal strength, and ball-throwing velocity
( MDPI AG , 2019 , Article)This study assessed the impact of 8 weeks biweekly in-season weightlifting training on the strength, throwing ability, and body composition of healthy male handball players. Twenty players (age: 21.2 ± 0.7 years, height: ... -
In-service video-vibration monitoring for identification of walking patterns in an office floor
( International Institute of Acoustics and Vibration, IIAV , 2018 , Conference Paper)Footfall-induced vibrations in office floors can create significant problems for the occupants and facility owners. Such vibrations cannot be modeled by traditional load models since the vibration response of a floor depends ...