Browsing Faculty Contributions by Subject "Biomarkers"
Now showing items 1-20 of 28
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A smartphone-interfaced, low-cost colorimetry biosensor for selective detection of bronchiectasis via an artificial neural network
( Royal Society of Chemistry , 2022 , Article)Exhaled breath (EB) contains several macromolecules that can be exploited as biomarkers to provide clinical information about various diseases. Hydrogen peroxide (H2O2) is a biomarker because it indicates bronchiectasis ... -
Accuracy of procalcitonin for diagnosing sepsis in adult patients admitted to the emergency department: a systematic review and meta-analysis
( BioMed Central Ltd , 2024 , Article Review)Background Differentiating sepsis from non-infectious systemic inflammatory response syndrome (SIRS) is challenging. Biomarkers like procalcitonin (PCT) aid early risk assessment and guide antibiotic use. This study aims ... -
Biofluid proteomics and biomarkers in traumatic brain injury
( Humana Press Inc. , 2017 , Book chapter)Traumatic brain injury (TBI) is an injury to the brain caused by an external mechanical force, affecting millions of people worldwide. The disease course and prognosis are often unpredictable, and it can be challenging to ... -
Bioinformatics investigation on blood-based gene expressions of Alzheimer's disease revealed ORAI2 gene biomarker susceptibility: An explainable artificial intelligence-based approach
( Springer , 2023 , Article)The progressive, chronic nature of Alzheimer's disease (AD), a form of dementia, defaces the adulthood of elderly individuals. The pathogenesis of the condition is primarily unascertained, turning the treatment efficacy ... -
BRIP1 overexpression is correlated with clinical features and survival outcome of luminal breast cancer subtypes
( BioScientifica Ltd. , 2018 , Article)In Oman, breast cancer is most common, representing approximately more than 25% of all cancers in women. Relatively younger populations of patients (25-40 years) present surprisingly with an aggressive phenotype and advanced ... -
Can atorvastatin with metformin change the natural history of prostate cancer as characterized by molecular, metabolomic, imaging and pathological variables? A randomized controlled trial protocol
( Elsevier , 2016 , Article)Background Atorvastatin and metformin are known energy restricting mimetic agents that act synergistically to produce molecular and metabolic changes in advanced prostate cancer (PCa). This trial seeks to determine whether ... -
Cerebrospinal fluid α-synuclein species in cognitive and movements disorders
( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)Total CSF α-synuclein (t-α-syn), phosphorylated α-syn (pS129-α-syn) and α-syn oligomers (o-α-syn) have been studied as candidate biomarkers for synucleinopathies, with suboptimal specificity and sensitivity in the ... -
Corneal nerve loss in patients with TIA and acute ischemic stroke in relation to circulating markers of inflammation and vascular integrity
( Nature Research , 2022 , Article)Vascular and inflammatory mechanisms are implicated in the development of cerebrovascular disease and corneal nerve loss occurs in patients with transient ischemic attack (TIA) and acute ischemic stroke (AIS). We have ... -
COVID-19 Severity in Patients With Apical Periodontitis: A Case Control Study
( Elsevier , 2024 , Article)Objectives: Apical periodontitis (AP) has been associated with systemic inflammatory biomarkers that have also been associated with COVID-19 severity. This study was designed to test the hypothesis that the presence of ... -
Development and Validation of an Early Scoring System for Prediction of Disease Severity in COVID-19 Using Complete Blood Count Parameters
( Institute of Electrical and Electronics Engineers Inc. , 2021 , Article)The coronavirus disease 2019 (COVID-19) after outbreaking in Wuhan increasingly spread throughout the world. Fast, reliable, and easily accessible clinical assessment of the severity of the disease can help in allocating ... -
Exploring serum glycome patterns after moderate to severe traumatic brain injury: A prospective pilot study
( Elsevier , 2022 , Article)BackgroundGlycans play essential functional roles in the nervous system and their pathobiological relevance has become increasingly recognized in numerous brain disorders, but not fully explored in traumatic brain injury ... -
Finding Behavioural and Imaging Biomarkers of Major Depressive Disorder (MDD) using Artificial Intelligence: A Review
( Institute of Electrical and Electronics Engineers Inc. , 2020 , Conference Paper)Major Depressive Disorder (MDD) is a serious ailment in mental health and is a medical illness that has a debilitating impact on a person's ability to think effectively. According to the World Health Organization (WHO), ... -
Gene expression and miRNAs profiling: Function and regulation in human epidermal growth factor receptor 2 (HER2) - positive breast cancer
( MDPI AG , 2019 , Article)Breast cancer is the second most common cause of cancer-related deaths among women worldwide. It is a heterogeneous disease with four major molecular subtypes. One of the subtypes, human epidermal growth factor receptor 2 ... -
The identification of highly upregulated genes in claudin-low breast cancer through an integrative bioinformatics approach
( Elsevier , 2020 , Article)Breast cancer (BC) is one of the leading causes of cancer-related death among women worldwide, and claudin-low breast cancer (CLBC) is a subtype of BC that remains poorly described. This study aimed to identify upregulated ... -
Imaging cancer cells with nanostructures: Prospects of nanotechnology driven non-invasive cancer diagnosis
( Elsevier B.V. , 2021 , Article)The application of nanostructured materials in medicine is a rapidly evolving area of research that includes both the diagnosis and treatment of various diseases. Metals, metal oxides and carbon-based nanomaterials have ... -
Inflammasomes as biomarkers and therapeutic targets in traumatic brain injury and related-neurodegenerative diseases: A comprehensive overview
( Elsevier , 2023 , Article)Given the ambiguity surrounding traumatic brain injury (TBI) pathophysiology and the lack of any Food and Drug Administration (FDA)-approved neurotherapeutic drugs, there is an increasing need to better understand the ... -
Integrated datasets of proteomic and metabolomic biomarkers to predict its impacts on comorbidities of type 2 diabetes mellitus
( Dove Medical Press , 2020 , Article)© 2020 Cheema et al. Objective: The objective of the current study is to accomplish a relative exploration of the biological roles of differentially dysregulated genes (DRGs) in type 2 diabetes mellitus (T2DM). The study ... -
Investigation of differentially expressed genes and dysregulated pathways involved in multiple sclerosis
( Elsevier , 2022 , Book chapter)Multiple Sclerosis (MS) is a neurodegenerative autoimmune and organ-specific demyelinating disorder, known to affect the central nervous system (CNS). While genetic studies have revealed several critical genes and diagnostic ... -
iTRAQ-based quantitative protein expression profiling and MRM verification of markers in type 2 diabetes.
( American Chemical Society , 2012 , Article)The pathogenesis of Type 2 diabetes mellitus (T2DM) is complex owing to molecular heterogeneity in the afflicted population. Current diagnostic methods rely on blood glucose measurements, which are noninformative with ... -
Methodological considerations for identifying multiple plasma proteins associated with all-cause mortality in a population-based prospective cohort
( Nature Research , 2021 , Article)Novel methods to characterize the plasma proteome has made it possible to examine a wide range of proteins in large longitudinal cohort studies, but the complexity of the human proteome makes it difficult to identify robust ...