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Congenital microcephaly-linked CDK5RAP2 affects eye development
(
Wiley
, 2020 , Article)
Biallelic mutations in the cyclin-dependent kinase 5 regulatory subunit-associated protein 2 gene CDK5RAP2 cause autosomal recessive primary microcephaly type 3 (MCPH3). MCPH is characterized by intellectual disability and ...
Vitamin D Signaling in Inflammation and Cancer: Molecular Mechanisms and Therapeutic Implications
(
MDPI
, 2020 , Article Review)
Vitamin D and its active metabolites are important nutrients for human skeletal health. UV irradiation of skin converts 7-dehydrocholesterol into vitamin D3, which metabolized in the liver and kidneys into its active form, ...
Co‑prevalence of human Papillomaviruses (HPV) and Epstein–Barr virus (EBV) in healthy blood donors from diverse nationalities in Qatar
(
BMC
, 2020 , Article)
Background: Infections by both human oncoviruses, human Papillomaviruses (HPV) and Epstein–Barr virus (EBV) are
very common in the adult human population and are associated with various malignancies. While HPV is ...
Women-Only Cardiac Rehabilitation Delivery Around the World
(
Elsevier
, 2020 , Article & Conference Proceedings)
Background: Women utilize cardiac rehabilitation (CR) significantly less than men. Gender-tailored CR improves adherence and mental
health outcomes when compared to traditional programs. This study ascertained the ...
Targeting HER2 expression in cancer: New drugs and new indications.
(
Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
, 2020 , Article)
Functional activation of human epidermal growth factor receptor 2 (HER2) has been shown to strongly promote carcinogenesis, leading to the investigation of HER2-directed agents in cancers with HER2 genomic alterations. ...
Willingness to participate in genome testing: a survey of public attitudes from Qatar
(
Springer
, 2020 , Article)
Genomics has the potential to revolutionize medical approaches to disease prevention, diagnosis, and treatment, but it does not come without challenges. The success of a national population-based genome program, like the ...
A low glycemic diet protects disease-prone Nrf2-deficient mice against age-related macular degeneration.
(
Elsevier
, 2020 , Article)
Age-related macular degeneration (AMD) is a major blinding disease, affecting over 14% of the elderly. Risk for AMD is related to age, diet, environment, and genetics. Dietary modulation of AMD risk is a promising treatment ...
The Expression of TBC1 Domain Family, Member 4 (TBC1D4) in Skeletal Muscles of Insulin-Resistant Mice in Response to Sulforaphane
(
Endocrine Society
, 2020 , Conference Paper)
The Expression of TBC1 Domain Family, member 4 (TBC1D4) in Skeletal Muscles of Insulin-Resistant Mice in Response to Sulforaphane.
Background: Obesity is commonly accompanied by impaired glucose homeostasis. Decreased ...
المشكلات القانونية المتعلقة بأخلاقيات علم الأحياء في القانون المقارن
(
كلية الحقوق - جامعة المنصورة
, 2020 , Article)
موضوع البحث:
ظهر في وقت ليس ببعيد فرع جديد من العلوم والمعارف البينية وهو أخلاقيات علم الأحياء. هذا الفرع لا ينتمي خالصا إلى العلوم الطبية بل هو مزيج من المعرفة الطبية والقانون والأخلاقيات بوجه عام مع وجود جانب للفلسفة ...
Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the State of Qatar
(
Wiley Open Access
, 2020 , Article)
Several studies showed that aberrant DNA methylation is involved in leukemia and cancer pathogenesis. Protein tyrosine phosphatase receptor gamma (PTPRG) expression is a natural inhibitory mechanism that is downregulated ...