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The Role of p90 Ribosomal S6 Kinase (RSK) in Tyrosine Kinase Inhibitor (TKI)-Induced Cardiotoxicity
(
Springer
, 2023 , Article Review)
Targeted therapy, such as tyrosine kinase inhibitors (TKIs), has been approved to manage various cancer types. However, TKI-induced cardiotoxicity is a limiting factor for their use. This issue has raised the need for ...
Biochemical and cellular basis of oxidative stress: Implications for disease onset
(
Wiley
, 2023 , Article Review)
Cellular oxidation–reduction (redox) systems, which encompass pro- and antioxidant molecules, are integral components of a plethora of essential cellular processes. Any dysregulation of these systems can cause molecular ...
Small Cell Lung Carcinoma: Current Diagnosis, Biomarkers, and Treatment Options with Future Perspectives
(
MDPI
, 2023 , Article Review)
Small cell lung cancer (SCLC) is an aggressive malignancy characterized by rapid proliferation, early dissemination, acquired therapy resistance, and poor prognosis. Early diagnosis of SCLC is crucial since most patients ...
The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: An Update with Meta-analysis
(
Springer Science and Business Media B.V.
, 2023 , Article Review)
Background and Aim
The impact of multiple risk factors on COVID-19 mortality has been previously reported in multiple systematic reviews and meta-analyses. The aim of this review is to provide a comprehensive update on ...
MDM2- an indispensable player in tumorigenesis
(
Springer Science and Business Media B.V.
, 2023 , Article Review)
Murine double minute 2 (MDM2) is a well-recognized molecule for its oncogenic potential. Since its identification, various cancer-promoting roles of MDM2 such as growth stimulation, sustained angiogenesis, metabolic ...
Does the Mediterranean Diet Have Any Effect on Lipid Profile, Central Obesity and Liver Enzymes in Non-Alcoholic Fatty Liver Disease (NAFLD) Subjects? A Systematic Review and Meta-Analysis of Randomized Control Trials
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2023 , Article Review)
The effectiveness of the Mediterranean diet (MD) in non-alcoholic fatty liver disease (NAFLD) subjects has been evaluated in several randomized controlled trials (RCTs). This systematic review and meta-analysis aimed to ...
Stress Factors as Possible Regulators of Pluripotent Stem Cell Survival and Differentiation
(
MDPI
, 2023 , Article Review)
In recent years, extensive research efforts have been directed toward pluripotent stem cells, primarily due to their remarkable capacity for pluripotency. This unique attribute empowers these cells to undergo self-renewal ...
Preclinical orofacial pain assays and measures and chronic primary orofacial pain research: where we are and where we need to go
(
Frontiers Media S.A.
, 2023 , Article Review)
Chronic primary orofacial pain (OFP) conditions such as painful temporomandibular disorders (pTMDs; i.e., myofascial pain and arthralgia), idiopathic trigeminal neuralgia (TN), and burning mouth syndrome (BMS) are seemingly ...
Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope
(
Taylor and Francis Ltd.
, 2023 , Article Review)
Boronic acids/esters have recently emerged in the field of medicinal and pharmaceutical research due to their exceptional oxophilicity, low toxicity, and unique structure. They are known as potent enzyme inhibitors, cancer ...
Epidemiology of herpes simplex virus type 1 in Canada: systematic review, meta-analyses, and meta-regressions
(
Frontiers Media SA
, 2023 , Article Review)
Background: The objective of this study was to characterize herpes simplex virus type 1 (HSV-1) epidemiology in Canada.
Methods: HSV-1 publications as recent as December 6, 2021 were systematically reviewed, synthesized, ...