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    Small Cell Lung Carcinoma: Current Diagnosis, Biomarkers, and Treatment Options with Future Perspectives

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    biomedicines-11-01982.pdf (1.001Mb)
    Date
    2023
    Author
    Krpina, Kristina
    Vranić, Semir
    Tomić, Krešimir
    Samaržija, Miroslav
    Batičić, Lara
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    Abstract
    Small cell lung cancer (SCLC) is an aggressive malignancy characterized by rapid proliferation, early dissemination, acquired therapy resistance, and poor prognosis. Early diagnosis of SCLC is crucial since most patients present with advanced/metastatic disease, limiting the potential for curative treatment. While SCLC exhibits initial responsiveness to chemotherapy and radiotherapy, treatment resistance commonly emerges, leading to a five-year overall survival rate of up to 10%. New effective biomarkers, early detection, and advancements in therapeutic strategies are crucial for improving survival rates and reducing the impact of this devastating disease. This review aims to comprehensively summarize current knowledge on diagnostic options, well-known and emerging biomarkers, and SCLC treatment strategies and discuss future perspectives on this aggressive malignancy.
    DOI/handle
    http://dx.doi.org/10.3390/biomedicines11071982
    http://hdl.handle.net/10576/49438
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    • Medicine Research [‎1794‎ items ]

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