Search
Now showing items 1-3 of 3
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
(
Elsevier
, 2022 , Article)
A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ...
Repositioning of the global epicentre of non-optimal cholesterol
(
Nature Research
, 2020 , Article)
High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using ...
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
(
BioMed Central
, 2022 , Article)
Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding ...