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Inhibition of p90 ribosomal S6 kinase potentiates cisplatin activity in A549 human lung adenocarcinoma cells
(
Wiley
, 2020 , Article)
© 2020 Royal Pharmaceutical Society Aim: Cisplatin is a standard treatment approach against lung adenocarcinoma. Resistance to cisplatin and the toxic side effects of cisplatin continue to remain a challenge. Combining ...
MXene Nanosheets May Induce Toxic Effect on the Early Stage of Embryogenesis.
(
American Scientific Publishers
, 2020 , Article)
MXene (Ti₃C₂T), as a novel 2D material, has produced a great interest due to its promising properties in biomedical applications, nevertheless, there is a lack of studies dedicated to investigate the possible toxic effect ...
Exosomes: Multiple-targeted multifunctional biological nanoparticles in the diagnosis, drug delivery, and imaging of cancer cells
(2020 , Article)
Exosomes are biological nanoparticles (30−150 nm) secreted in the extracellular area from all of cells, that mediate intercellular message. Exosomes act as the carriers for numerous proteins, DNAs, RNAs and cell-signaling ...
Loop-mediated isothermal amplification (Lamp): A rapid, sensitive, specific, and cost-effective point-of-care test for coronaviruses in the context of covid-19 pandemic
(
MDPI
, 2020 , Article)
The rampant spread of COVID-19 and the worldwide prevalence of infected cases demand a rapid, simple, and cost-effective Point of Care Test (PoCT) for the accurate diagnosis of this pandemic. The most common molecular tests ...
Combined chemo-magnetic field-photothermal breast cancer therapy based on porous magnetite nanospheres
(
Nature Research
, 2020 , Article)
The efficacy of different modalities of treating breast cancer is inhibited by several limitations such as off-targeted drug distribution, rapid drug clearance, and drug resistance. To overcome these limitations, we developed ...
Targeting SARS-CoV2 Spike Protein Receptor Binding Domain by Therapeutic Antibodies
(
Elsevier
, 2020 , Article)
The Authors As the number of people infected with the newly identified 2019 novel coronavirus (SARS-CoV2) is continuously increasing every day, development of potential therapeutic platforms is vital. Based on the comparatively ...
Natural halloysite nanotubes /chitosan based bio-nanocomposite for delivering norfloxacin, an anti-microbial agent in sustained release manner
(
Elsevier B.V.
, 2020 , Article)
Applying nanotechnology to deliver drug could result in several benefits such as prolong duration of action, enhancement in overall bioavailability, targeting to specific site, low initial loading dose require, systemic ...
Nanozyme-based sensing platforms for detection of toxic mercury ions: An alternative approach to conventional methods
(
Elsevier B.V.
, 2020 , Article)
Mercury (Hg) is known as a poisonous heavy metal which stimulates a wide range of adverse effects on the human health. Therefore, development of some feasible, practical and highly sensitive platforms would be desirable ...
Exploring the interaction of synthesized nickel oxide nanoparticles through hydrothermal method with hemoglobin and lymphocytes: Bio-thermodynamic and cellular studies
(
Elsevier B.V.
, 2020 , Article)
The NiO NPs were synthesized by hydrothermal method and their interaction with Hb was investigated by employing fluorescence, UV?vis absorption techniques as well as docking studies. Also, the cytotoxic impacts of NiO NPs ...
Enzyme immobilization onto the nanomaterials: Application in enzyme stability and prodrug-activated cancer therapy
(
Elsevier B.V.
, 2020 , Article)
Nanoparticles (NPs) have been widely used for immobilization of wide ranges of enzymes. However, the stabilization of enzymes on NPs is a major challenge, crucial for regulating enzymatic activity and their medical ...