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Novel therapeutic targets in salivary duct carcinoma uncovered by comprehensive molecular profiling.

Gargano, Stacey M; Senarathne, Wijendra; Feldman, Rebecca; Florento, Elena; Stafford, Phillip; ... more authors ... less authors ( Wiley Open Access , 2019 , Article)

Salivary duct carcinoma (SDC) is a rare, aggressive salivary gland malignancy, which often presents at an advanced stage. A proportion of SDC are characterized by HER2 amplification and/or overexpression of androgen receptor ...

Triple Negative Breast Cancer Profile, from Gene to microRNA, in Relation to Ethnicity.

Gupta, Ishita; Sareyeldin, Rasha M.; Al-Hashimi, Israa; Al-Thawadi, Hamda A.; Al Farsi, Halema; ... more authors ... less authors ( MDPI , 2019 , Article)

Breast cancer is the most frequent cause of cancer-related deaths among women worldwide. It is classified into four major molecular subtypes. Triple-negative breast cancers (TNBCs), a subgroup of breast cancer, are defined ...

Circulating microparticles as biomarkers of stroke: A focus on the value of endothelial- and platelet-derived microparticles.

El-Gamal, Heba; Parray, Aijaz S; Mir, Fayaz A; Shuaib, Ashfaq; Agouni, Abdelali ( Wiley , 2019 , Article)

Stroke is one of the leading causes of mortality and disability worldwide. Numerous pathophysiological mechanisms involving blood vessels, coagulation and inflammation contribute to the vascular occlusion. Perturbations ...

Integrative Bioinformatics Approaches to Map Potential Novel Genes and Pathways Involved in Ovarian Cancer.

Kumar, S Udhaya; Kumar, D Thirumal; R, Siva; Doss, C George Priya; Zayed, Hatem ( Frontiers Media , 2019 , Article)

Ovarian cancer (OC) is the seventh most commonly detected cancer among women. This study aimed to map the hub and core genes and potential pathways that might be involved in the molecular pathogenesis of OC. In the present ...

Biomarkers of Targeted Therapy and Immuno-Oncology in Cancers Metastatic to the Breast.

Vranic, Semir; Senarathne, Wijendra; Stafford, Phillip; Poorman, Kelsey; Pockaj, Barbara A; ... more authors ... less authors ( Lippincott, Williams & Wilkins , 2019 , Article)

The breast is a rare site for metastases, and their molecular characteristics have not been studied yet. Intrinsic molecular genetics, cancer characteristics, and breast tissue immune responses in diverse metastases to the ...

There Is Selective Increase in Pro-thrombotic Circulating Extracellular Vesicles in Acute Ischemic Stroke and Transient Ischemic Attack: A Study of Patients From the Middle East and Southeast Asia.

Agouni, Abdelali; Parray, Aijaz S; Akhtar, Naveed; Mir, Fayaz A; Bourke, Paula J; ... more authors ... less authors ( Frontiers Media , 2019 , Article)

Stroke attacks were found to be present at a younger age in patients from Southeast Asia (SE) and the Middle East (ME) resident in the state of Qatar. Extracellular vesicles (EVs), which are small membrane vesicles with ...