تصفح Pharmacy Research حسب المؤلف "Akhtar, Sabah"
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Guggulsterone Induces Apoptosis in Multiple Myeloma Cells by Targeting High Mobility Group Box 1 via Janus Activated Kinase/Signal Transducer and Activator of Transcription Pathway
Akhtar, Sabah; Zarif, Lubna; Kuttikrishnan, Shilpa; Prabhu, Kirti S.; Patil, Kalyani; Nisar, Sabah; Abou-Saleh, Haissam; Merhi, Maysaloun; Dermime, Said; Bhat, Ajaz A.; Uddin, Shahab... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Multiple myeloma (MM) is a hematological disorder characterized by the abnormal expansion of plasma cells in the bone marrow. Despite great advances over the past three decades in discovering the efficacious therapies for ... -
Role of HMGB1 and its associated signaling pathways in human malignancies
Sourour, Idoudi; Bedhiafi, Takwa; Pedersen, Shona; Elahtem, Mohamed; Alremawi, Izzaldin; Akhtar, Sabah; Dermime, Said; Merhi, Maysaloun; Uddin, Shahab... more authors ... less authors ( Elsevier , 2023 , Article)The High-Mobility Group Box-1 (HMGB1), a non-histone chromatin-associated protein, plays a crucial role in cancer growth and response to therapy as it retains a pivotal role in promoting both cell death and survival. HMGB1 ... -
Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents
Sheema, Hashem; Ali, Tayyiba Akbar; Akhtar, Sabah; Nisar, Sabah; Sageena, Geetanjali; Ali, Shahid; Al-Mannai, Sharefa; Therachiyil, Lubna; Mir, Rashid; Elfaki, Imadeldin; Mir, Mohammad Muzaffar; Jamal, Farrukh; Masoodi, Tariq; Uddin, Shahab; Singh, Mayank; Haris, Mohammad; Macha, Muzafar; Bhat, Ajaz A.... more authors ... less authors ( Elsevier , 2022 , Article Review)Cancer is one of the leading causes of death and significantly burdens the healthcare system. Due to its prevalence, there is undoubtedly an unmet need to discover novel anticancer drugs. The use of natural products as ...