Browsing Pharmacy Research by Author "Yalcin, Huseyin C."
Now showing items 1-5 of 5
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Deep Learning Technique for Congenital Heart Disease Detection Using Stacking-Based CNN-LSTM Models from Fetal Echocardiogram: A Pilot Study
Rahman, Tawsifur; Al-Ruweidi, Mahmoud Khatib A.A.; Sumon, Md Shaheenur Islam; Kamal, Reema Yousef; Chowdhury, Muhammad E.H.; Yalcin, Huseyin C.... more authors ... less authors ( IEEE , 2023 , Article)Congenital heart defects (CHDs) are a leading cause of death in infants under 1 year of age. Prenatal intervention can reduce the risk of postnatal serious CHD patients, but current diagnosis is based on qualitative criteria, ... -
Exploring the in vivo anti-cancer potential of Neosetophomone B in leukemic cells using a zebrafish xenograft model
Kuttikrishnan, Shilpa; Hasan, Maram; Prabhu, Kirti S.; El-Elimat, Tamam; Oberlies, Nicholas H.; Pearce, Cedric J.; Alali, Feras Q.; Ahmad, Aamir; Pourkarimi, Ehsan; Bhat, Ajaz A.; Yalcin, Huseyin C.; Uddin, Shahab... more authors ... less authors ( Elsevier Inc. , 2024 , Article)Neosetophomone B (NSP–B) is a unique meroterpenoid fungal secondary metabolite that has previously demonstrated promising anti-cancer properties against various cancer cell lines in vitro. However, its in vivo anti-cancer ... -
Reduced Cardiotoxicity of Ponatinib-Loaded PLGA-PEG-PLGA Nanoparticles in Zebrafish Xenograft Model.
Al-Thani, Hissa F; Shurbaji, Samar; Zakaria, Zain Zaki; Hasan, Maram H; Goracinova, Katerina; Korashy, Hesham M; Yalcin, Huseyin C... more authors ... less authors ( MDPI , 2022 , Article)Tyrosine kinase inhibitors (TKIs) are the new generation of anti-cancer drugs with high potential against cancer cells' proliferation and growth. However, TKIs are associated with severe cardiotoxicity, limiting their ... -
The Role of p90 Ribosomal S6 Kinase (RSK) in Tyrosine Kinase Inhibitor (TKI)-Induced Cardiotoxicity
Suleiman, Muna; Al Najjar, Afnan; Zakaria, Zain Z.; Ahmed, Rashid; Yalcin, Huseyin C.; Korashy, Hesham M.; Uddin, Shahab; Riaz, Sadaf; Abdulrahman, Nabeel; Mraiche, Fatima... more authors ... less authors ( Springer , 2023 , Article Review)Targeted therapy, such as tyrosine kinase inhibitors (TKIs), has been approved to manage various cancer types. However, TKI-induced cardiotoxicity is a limiting factor for their use. This issue has raised the need for ... -
Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity
zakaria, zain z.; benslimane, fatiha m.; nasrallah, gheyath k.; shurbaji, samar; younes, nadin n.; Mraiche, Fatima; Da’as, Sahar I.; yalcin, huseyin c.... more authors ... less authors ( Hindawi Publishing Corporation , 2018 , Article)Over the last decade, the zebrafish (Danio rerio) has emerged as amodel organismfor cardiovascular research.Zebrafish have several advantages over mammalian models. For instance, the experimental cost of using zebrafish ...