Browsing Pharmacy Research by Author "Bhat, Ajaz A."
Now showing items 1-8 of 8
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Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells
Kuttikrishnan, Shilpa; Bhat, Ajaz A.; Mateo, Jericha M.; Ahmad, Fareed; Alali, Feras Q.; El-Elimat, Tamam; Oberlies, Nicholas H.; Pearce, Cedric J.; Uddin, Shahab... more authors ... less authors ( Elsevier , 2022 , Article)Neosetophomone B (NSP–B), a meroterpenoid fungal secondary metabolite, was investigated for its anticancer potential in leukemic cell lines (K562 and U937). NSP-B treatment of leukemic cells suppressed cell viability by ... -
Bioinformatics Analysis Reveals FOXM1/BUB1B Signaling Pathway as a Key Target of Neosetophomone B in Human Leukemic Cells: A Gene Network-Based Microarray Analysis
Kuttikrishnan, Shilpa; Masoodi, Tariq; Sher, Gulab; Bhat, Ajaz A.; Patil, Kalyani; El-Elimat, Tamam; Oberlies, Nicholas H.; Pearce, Cedric J.; Haris, Mohmmad; Ahmad, Aamir; Alali, Feras Q.; Uddin, Shahab... more authors ... less authors ( Frontiers Media S.A. , 2022 , Article)Abnormal expression of Forkhead box protein M1 (FOXM1) and serine/threonine kinase Budding uninhibited by benzimidazoles 1 (BUB1B) contributes to the development and progression of several cancers, including chronic ... -
Epigenetic inhibitors and their role in cancer therapy
Abdelaziz, Nouha; Therachiyil, Lubna; Sadida, Hana Q.; Ali, Ateeque Mohamed; Khan, Omar S.; Singh, Mayank; Khan, Abdul Q.; Akil, Ammira S.Al Shabeeb; Bhat, Ajaz A.; Uddin, Shahab... more authors ... less authors ( Elsevier , 2023 , Article)Epigenetic modifications to DNA are crucial for normal cellular and biological functioning. DNA methylation, histone modifications, and chromatin remodeling are the most common epigenetic mechanisms. These changes are ... -
Exploring the in vivo anti-cancer potential of Neosetophomone B in leukemic cells using a zebrafish xenograft model
Kuttikrishnan, Shilpa; Hasan, Maram; Prabhu, Kirti S.; El-Elimat, Tamam; Oberlies, Nicholas H.; Pearce, Cedric J.; Alali, Feras Q.; Ahmad, Aamir; Pourkarimi, Ehsan; Bhat, Ajaz A.; Yalcin, Huseyin C.; Uddin, Shahab... more authors ... less authors ( Elsevier Inc. , 2024 , Article)Neosetophomone B (NSP–B) is a unique meroterpenoid fungal secondary metabolite that has previously demonstrated promising anti-cancer properties against various cancer cell lines in vitro. However, its in vivo anti-cancer ... -
Guggulsterone Induces Apoptosis in Multiple Myeloma Cells by Targeting High Mobility Group Box 1 via Janus Activated Kinase/Signal Transducer and Activator of Transcription Pathway
Akhtar, Sabah; Zarif, Lubna; Kuttikrishnan, Shilpa; Prabhu, Kirti S.; Patil, Kalyani; Nisar, Sabah; Abou-Saleh, Haissam; Merhi, Maysaloun; Dermime, Said; Bhat, Ajaz A.; Uddin, Shahab... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Multiple myeloma (MM) is a hematological disorder characterized by the abnormal expansion of plasma cells in the bone marrow. Despite great advances over the past three decades in discovering the efficacious therapies for ... -
Neosetophomone B induces apoptosis in multiple myeloma cells via targeting of AKT/SKP2 signaling pathway
Kuttikrishnan, Shilpa; Ahmad, Fareed; Mateo, Jericha M.; Prabhu, Kirti S.; El-Elimat, Tamam; Oberlies, Nicholas H.; Pearce, Cedric J.; Akil, Ammira S.Alshabeeb; Bhat, Ajaz A.; Alali, Feras Q.; Uddin, Shahab... more authors ... less authors ( Wiley-Blackwell , 2023 , Article)Multiple myeloma (MM) is a hematologic malignancy associated with malignant plasma cell proliferation in the bone marrow. Despite the available treatments, drug resistance and adverse side effects pose significant challenges, ... -
Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells
Queenie, Fernandes; Therachiyil, Lubna; Khan, Abdul Q.; Bedhiafi, Takwa; Korashy, Hesham M; Bhat, Ajaz A.; Uddin, Shahab... more authors ... less authors ( Elsevier , 2023 , Article)Cancer remains one of the leading causes of mortality worldwide, presenting a significant healthcare challenge owing to the limited efficacy of current treatments. The application of nanotechnology in cancer treatment ... -
Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents
Sheema, Hashem; Ali, Tayyiba Akbar; Akhtar, Sabah; Nisar, Sabah; Sageena, Geetanjali; Ali, Shahid; Al-Mannai, Sharefa; Therachiyil, Lubna; Mir, Rashid; Elfaki, Imadeldin; Mir, Mohammad Muzaffar; Jamal, Farrukh; Masoodi, Tariq; Uddin, Shahab; Singh, Mayank; Haris, Mohammad; Macha, Muzafar; Bhat, Ajaz A.... more authors ... less authors ( Elsevier , 2022 , Article Review)Cancer is one of the leading causes of death and significantly burdens the healthcare system. Due to its prevalence, there is undoubtedly an unmet need to discover novel anticancer drugs. The use of natural products as ...