تصفح Pharmacy Research حسب المؤلف "Najlah, Mohammad"
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A simple approach to predict the stability of phospholipid vesicles to nebulization without performing aerosolization studies
Subramanian, Sneha; Khan, Iftikhar; Korale, Oshadie; Alhnan, Mohamed Albed; Ahmed, Waqar; Najlah, Mohammad; Taylor, Kevin M.G.; Elhissi, Abdelbary... more authors ... less authors ( Elsevier B.V. , 2016 , Article)Membrane extrusion was investigated for predicting the stability of soya phosphatidylcholine liposomes and surfactosomes (Tween 80-enriched liposomes) to nebulization. Formulations were prepared with or without cholesterol, ... -
Amlexanox-loaded nanoliposomes showing enhanced anti-inflammatory activity in cultured macrophages: A potential formulation for treatment of oral aphthous stomatitis
Abouzid, Afaf; Moustafa, Abdelrhman Y.; Allcock, Natalie; Najlah, Mohammad; Elhissi, Abdelbary; Stanley, Chi Wi; Ahmed, Waqar; Seville, Peter; Crean, StJohn; Forbes, Robert T.; Elsawy, Mohamed A.... more authors ... less authors ( Elsevier , 2023 , Article)Oral aphthous stomatitis is a common disorder treated with the immunomodulatory drug Amlexanox (AMX), that was administered as a mucoadhesive paste (Aphthasol®). This product was discontinued by FDA in 2014 due to the ... -
Carbon nanotubes drug delivery system for cancer treatment
Banu, Abdallah; Elhissi, Abdelbary M.A.; Ahmed, Waqar; Najlah, Mohammad ( Academic Press , 2020 , Book chapter)There has been a predominant interest in using nanotechnology for drug delivery applications, especially for cite-specific targeting. Recently, interest in the potential of carbon nanotubes (CNT) to deliver bio-molecules ... -
Cyclodextrin diethyldithiocarbamate copper ii inclusion complexes: A promising chemotherapeutic delivery system against chemoresistant triple negative breast cancer cell lines
Said Suliman, Ammar; Khoder, Mouhamad; Tolaymat, Ibrahim; Webster, Matt; Alany, Raid G.; Wang, Weiguang; Elhissi, Abdelbary; Najlah, Mohammad... more authors ... less authors ( MDPI AG , 2021 , Article)Diethyldithiocarbamate Copper II (DDC-Cu) has shown potent anticancer activity against a wide range of cancer cells, but further investigations are hindered by its practical insolubility in water. In this study, inclusion ... -
Development, characterization and stability evaluation of ciprofloxacin-loaded parenteral nutrition nanoemulsions
Said Suliman, Ammar; Tom, Rose; Palmer, Kirsty; Tolaymat, Ibrahim; Younes, Husam M.; Arafat, Basel; Elhissi, Abdelbary M.A.; Najlah, Mohammad... more authors ... less authors ( Taylor and Francis , 2020 , Article)© 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group. In this study, two licensed total parenteral nanoemulsion formulations (Clinoleic® and Intralipid®) were loaded with ciprofloxacin (CP). The physicochemical ... -
Letrozole-loaded nonionic surfactant vesicles prepared via a slurry-based proniosome technology: Formulation development and characterization
Nada, Khudair; Agouni, Abdelali; Elrayess, Mohamed A.; Najlah, Mohammad; Younes, Husam M.; Elhissi, Abdelbary... more authors ... less authors ( Elsevier , 2020 , Article)Slurry-based Letrozole (LTZ)-loaded proniosomes were designed using sucrose or sorbitol as carriers and various ratios of cholesterol (CH) and Tween 80 (T80) as lipid composition. Proniosomes were hydrated and probe-sonicated ... -
Novel paclitaxel formulations solubilized by parenteral nutrition nanoemulsions for application against glioma cell lines
Najlah, Mohammad; Kadam, Alisha; Wan, Ka-Wai; Ahmed, Waqar; Taylor, Kevin M.G.; Elhissi, Abdelbary M.A... more authors ... less authors ( Elsevier, Ltd , 2016 , Article)The aim of this study is to investigate using nanoemulsion formulations as drug-delivery vehicles of paclitaxel (PX), a poor water-soluble anticancer drug. Two commercially available nanoemulsion fat formulations (Clinoleic ... -
Proliposome powder or tablets for generating inhalable liposomes using a medical nebulizer
Khan, Iftikhar; Yousaf, Sakib; Najlah, Mohammad; Ahmed, Waqar; Elhissi, Abdelbary ( Springer , 2021 , Article)© 2020, The Author(s). Purpose: The aim of this study was to develop and compare proliposome powder and proliposome tablet formulations for drug delivery from a Pari-LC Sprint nebulizer. Methods: Proliposome powders were ... -
Spray-Dried Proliposome Microparticles for High-Performance Aerosol Delivery Using a Monodose Powder Inhaler
Omer, H.; Omer, Huner K.; Hussein, Nozad R.; Ferraz, Amina; Najlah, Mohammad; Ahmed, Waqar; Taylor, Kevin M.G.; Elhissi, Abdelbary M.A.... more authors ... less authors ( Springer New York LLC , 2018 , Article)© 2018, American Association of Pharmaceutical Scientists. Proliposome formulations containing salbutamol sulphate (SS) were developed using spray drying, and the effects of carrier type (lactose monohydrate (LMH) or ... -
Taxane anticancer formulations: challenges and achievements
Abdelbary M.A., Elhissi; Mahmood, Rukhsana; Parveen, Ishrat; Vali, Asma; Najlah, Mohammad; Phoenix, David A.; Ahmed, Waqar... more authors ... less authors ( Academic Press , 2020 , Book chapter)Taxanes represent a prominent anticancer family. Paclitaxel and docetaxel are the most well-known taxanes owing to their activity against many types of cancers. The poor solubility of taxanes in water is a major obstacle ...