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A Review of Pharmacogenetics of Antimalarials and Associated Clinical Implications
( Springer-Verlag France , 2017 , Article Review)Genetic variability in drug-metabolizing enzymes and drug transporters is known to influence the pharmacokinetics of many drugs. Antimalarial drugs are a class of agents known to utilize metabolic and elimination pathways ... -
A Review of the Clinical Pharmacokinetics and Pharmacodynamics of Isavuconazole
( Springer-Verlag France , 2018 , Article Review)Invasive fungal infections are a major cause of morbidity and mortality, especially for immunocompromised patients. Treatment options are few and most are limited by safety and formulation concerns. Isavuconazole is a new ... -
Clinical and Pharmacokinetic Outcomes of Peak–Trough-Based Versus Trough-Based Vancomycin Therapeutic Drug Monitoring Approaches: A Pragmatic Randomized Controlled Trial
( Springer-Verlag France , 2019 , Article)Background Vancomycin therapeutic drug monitoring (TDM) is based on achieving 24-h area under the concentration–time curve to minimum inhibitory concentration cure breakpoints (AUC24/MIC). Approaches to vancomycin TDM ... -
Clinical Pharmacokinetics and Drug Interactions of Doravirine
( Springer-Verlag France , 2018 , Article Review)Doravirine is a new HIV-1 non-nucleoside reverse transcriptase inhibitor that has demonstrated a good efficacy and safety profile in clinical trials. It has a therapeutic profile that makes it an attractive option for ... -
Population Pharmacokinetics of Intravenous Methotrexate in Patients with Hematological Malignancies: Utilization of Routine Clinical Monitoring Parameters
( Springer-Verlag France , 2017 , Article)Background and Objective: Clinical response to methotrexate in cancer is variable and depends on several factors including serum drug exposure. This study aimed to develop a population pharmacokinetic model describing ...