Browsing Pharmacy Research by Publisher "MDPI AG"
Now showing items 1-12 of 12
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7-O-methylpunctatin, a novel homoisoflavonoid, inhibits phenotypic switch of human arteriolar smooth muscle cells
( MDPI AG , 2019 , Article)Remodeling of arterioles is a pivotal event in the manifestation of many inflammation-based cardio-vasculopathologies, such as hypertension. During these remodeling events, vascular smooth muscle cells (VSMCs) switch from ... -
An original transformer and switched-capacitor (T & SC)-based extension for DC-DC boost converter for high-voltage/low-current renewable energy applications: Hardware implementation of a new T & SC boost converter
( MDPI AG , 2018 , Article)In this article a new Transformer and Switched Capacitor-based Boost Converter (T & SC-BC) is proposed for high-voltage/low-current renewable energy applications. The proposed T & SC-BC is an original extension for ... -
Availability of essential medicines in a country in conflict: A quantitative insight from Yemen
( MDPI AG , 2021 , Article)Background: Medicine and medical supplies are often in short supply in countries suffering from the scourge of conflict. Effective medicine supply policies are lacking in many low-and middle-income countries (LMICs), ... -
Cyclodextrin diethyldithiocarbamate copper ii inclusion complexes: A promising chemotherapeutic delivery system against chemoresistant triple negative breast cancer cell lines
( MDPI AG , 2021 , Article)Diethyldithiocarbamate Copper II (DDC-Cu) has shown potent anticancer activity against a wide range of cancer cells, but further investigations are hindered by its practical insolubility in water. In this study, inclusion ... -
Development of injectable PEGylated liposome encapsulating disulfiram for colorectal cancer treatment
( MDPI AG , 2019 , Article)Disulfiram (DS), an anti-alcoholism medicine, shows strong anti-cancer activity in the laboratory, but the application in clinics for anti-cancer therapy has been limited by its prompt metabolism. Conventional liposomes ... -
Epinephrine in anaphylaxis: Preclinical study of pharmacokinetics after sublingual administration of taste-masked tablets for potential pediatric use
( MDPI AG , 2018 , Article)Epinephrine is a life-saving treatment in anaphylaxis. In community settings, a first-aid dose of epinephrine is injected from an auto-injector (EAI). Needle phobia highly contributes to EAI underuse, leading to ... -
Greensporone A, a fungal secondary metabolite suppressed constitutively activated AKT via ROS generation and induced apoptosis in leukemic cell lines
( MDPI AG , 2019 , Article)Greensporone A is a fungal secondary metabolite that has exhibited potential in vitro for anti-proliferative activity in vitro. We studied the anticancer activity of greensporone A in a panel of leukemic cell lines. ... -
Lyophilized drug-loaded solid lipid nanoparticles formulated with beeswax and theobroma oil
( MDPI AG , 2021 , Article)Solid lipid nanoparticles (SLNs) have the potential to enhance the systemic availability of an active pharmaceutical ingredient (API) or reduce its toxicity through uptake of the SLNs from the gastrointestinal tract or ... -
New three-dimensional poly(decanediol-co-tricarballylate) elastomeric fibrous mesh fabricated by photoreactive electrospinning for cardiac tissue engineering applications
( MDPI AG , 2018 , Article)Reactive electrospinning is capable of efficiently producing in situ crosslinked scaffolds resembling the natural extracellular matrix with tunable characteristics. In this study, we aimed to synthesize, characterize, and ... -
Protein expression profiling identifies key proteins and pathways involved in growth inhibitory effects exerted by guggulsterone in human colorectal cancer cells
( MDPI AG , 2019 , Article)Colorectal cancer (CRC) is a leading killer cancer worldwide and one of the most common malignancies with increasing incidences of mortality. Guggulsterone (GS) is a plant sterol used for treatment of various ailments such ... -
Recent advancements in stimuli responsive drug delivery platforms for active and passive cancer targeting
( MDPI AG , 2021 , Article Review)The tumor-specific targeting of chemotherapeutic agents for specific necrosis of cancer cells without affecting the normal cells poses a great challenge for researchers and scientists. Though extensive research has been ... -
The role of protein tyrosine phosphatase (PTP)-1B in cardiovascular disease and its interplay with insulin resistance
( MDPI AG , 2019 , Article Review)Endothelial dysfunction is a key feature of cardiovascular disorders associated with obesity and diabetes. Several studies identified protein tyrosine phosphatase (PTP)-1B, a member of the PTP superfamily, as a major ...