Browsing Pharmacy Research by Subject "And binding free energy"

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Molecular exploration of natural and synthetic compounds databases for promising hypoxia inducible factor (HIF) Prolyl-4- hydroxylase domain (PHD) inhibitors using molecular simulation and free energy calculations

Sayaf, Abrar Mohammad; Kousar, Kafila; Suleman, Muhammad; Albekairi, Norah A.; Alshammari, AbdulRahman; Mohammad, Anwar; Khan, Abbas; Agouni, Abdelali; Yeoh, Kar Kheng... more authors ... less authors ( BioMed Central Ltd , 2024 , Article)
Hypoxia-inducible factors (HIFs) are transcription factors that regulate erythropoietin (EPO) synthesis and red blood cell (RBC) production. Prolyl-4-hydroxylase domain (PHD) enzymes are key regulators of HIF’s stability ...