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Nephroprotective Effects of Metformin in Diabetic Nephropathy
(
Wiley
, 2017 , Article)
Metformin, a well-known anti-diabetic agent, is very effective in lowering blood glucose in patients with type 2 diabetes with minimal side-effects. Metformin is also being recommended in the treatment of obesity and ...
Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases
(
Hindawi
, 2017 , Article)
Sestrin2 (SESN2), a highly conserved stress-inducible metabolic protein, is known to repress reactive oxygen species (ROS) and provide cytoprotection against various noxious stimuli including genotoxic and oxidative stress, ...
Metformin Attenuates Albumin-induced Alterations in Renal Tubular Cells In Vitro
(
Wiley Periodicals, Inc
, 2017 , Article)
Proteinuria (albuminuria) plays a crucial role in the etiology of chronic kidney disease (CKD) via alteration of multiple signaling pathways and cellular process in renal cells. The objectives of this study are to investigate ...