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AuthorButt, A.A.
AuthorButt, Adeel A.
AuthorDargham, Soha R.
AuthorLoka, Srusvin
AuthorShaik, Riyazuddin M.
AuthorChemaitelly, Hiam
AuthorTang, Patrick
AuthorHasan, Mohammad R.
AuthorCoyle, Peter V.
AuthorYassine, Hadi M.
AuthorAl-Khatib, Hebah A.
AuthorSmatti, Maria K.
AuthorKaleeckal, Anvar H.
AuthorLatif, Ali Nizar
AuthorZaqout, Ahmed
AuthorAlmaslamani, Muna A.
AuthorAl Khal, Abdullatif
AuthorBertollini, Roberto
AuthorAbou-Samra, Abdul Badi
AuthorAbu-Raddad, Laith J.
Available date2022-09-12T15:13:28Z
Publication Date2022-08-24
Publication NameClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Identifierhttp://dx.doi.org/10.1093/cid/ciac275
CitationButt, A. A., Dargham, S. R., Loka, S., Shaik, R. M., Chemaitelly, H., Tang, P., ... & Abu-Raddad, L. J. (2022). Coronavirus disease 2019 disease severity in children infected with the omicron variant. Clinical Infectious Diseases, 75(1), e361-e367.‏
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85137125032&origin=inward
URIhttp://hdl.handle.net/10576/33884
AbstractSHORT SUMMARY: Severe acute respiratory syndrome coronavirus 2 infection from the Omicron variant in children/adolescents is less severe than infection from the Delta variant. Those 6 to <18 years also have less severe disease than those <6 years old. BACKGROUND: There are limited data assessing coronavirus 2019 (COVID-19) disease severity in children/adolescents infected with the Omicron variant. METHODS: We identified children and adolescents <18 years of age with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with Delta and propensity score-matched controls with Omicron variant infection from the National COVID-19 Database in Qatar. Primary outcome was disease severity, determined by hospital admission, admission to the intensive care unit (ICU), or mechanical ventilation within 14 days of diagnosis, or death within 28 days. RESULTS: Among 1735 cases with Delta variant infection between 1 June and 6 November 2021, and 32 635 cases with Omicron variant infection between 1 January and 15 January 2022, who did not have prior infection and were not vaccinated, we identified 985 propensity score-matched pairs. Among those who were Delta infected, 84.2% had mild, 15.7% had moderate, and 0.1% had severe/critical disease. Among those who were Omicron infected, 97.8% had mild, 2.2% had moderate, and none had severe/critical disease (P < .001). Omicron variant infection (vs Delta) was associated with significantly lower odds of moderate or severe/critical disease (adjusted odds ratio [AOR], 0.12; 95% confidence interval [CI], .07-.18). Those aged 6-11 and 12 to <18 years had lower odds of developing moderate or severe/critical disease compared with those younger than age 6 years (aOR, 0.47; 95% CI, .33-.66 for 6-11 year olds; aOR, 0.45; 95% CI, .21-.94 for 12 to <18 year olds). CONCLUSIONS: Omicron variant infection in children/adolescents is associated with less severe disease than Delta variant infection as measured by hospitalization rates and need for ICU care or mechanical ventilation. Those 6 to <18 years of age also have less severe disease than those <6 years old.
Languageen
PublisherNLM (Medline)
Subjectchildren
Delta variant
Omicron variant
outcomes
SARS-CoV-2
TitleCoronavirus Disease 2019 Disease Severity in Children Infected With the Omicron Variant
TypeArticle
Issue Number1
Volume Number75
dc.accessType Open Access


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