Show simple item record

AuthorDiboun, I.
AuthorDiboun, Ilhame
AuthorCyprian, Farhan S.
AuthorAnwardeen, Najeha Rizwana
AuthorYassine, Hadi M.
AuthorElrayess, Mohamed A.
AuthorRahmoon, Samreen Mumtaz
AuthorSayed, Sarah Khaled
AuthorSchuchardt, Sven
AuthorKhatib, Malkan
AuthorBansal, Devendra
AuthorFarag, Elmoubashar Abu Baker Abd
AuthorEmara, Mohamed M.
AuthorAbdallah, Abdallah M.
Available date2022-09-12T16:07:55Z
Publication Date2022-07-22
Publication NameFrontiers in Cellular and Infection Microbiology
Identifierhttp://dx.doi.org/10.3389/fcimb.2022.929689
CitationDiboun, I., Cyprian, F. S., Anwardeen, N. R., Yassine, H. M., Elrayess, M. A., Rahmoon, S. M., ... & Abdallah, A. M. (2022). Identification of Prognostic Metabolomic Biomarkers at the Interface of Mortality and Morbidity in Pre-Existing TB Cases Infected With SARS-CoV-2. Frontiers in Cellular and Infection Microbiology, 932.‏
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85135445140&origin=inward
URIhttp://hdl.handle.net/10576/33886
AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection currently remains one of the biggest global challenges that can lead to acute respiratory distress syndrome (CARDS) in severe cases. In line with this, prior pulmonary tuberculosis (TB) is a risk factor for long-term respiratory impairment. Post-TB lung dysfunction often goes unrecognized, despite its relatively high prevalence and its association with reduced quality of life. In this study, we used a metabolomics analysis to identify potential biomarkers that aid in the prognosis of COVID-19 morbidity and mortality in post-TB infected patients. This analysis involved blood samples from 155 SARS-CoV-2 infected adults, of which 23 had a previous diagnosis of TB (post-TB), while 132 did not have a prior or current TB infection. Our analysis indicated that the vast majority (~92%) of post-TB individuals showed severe SARS-CoV-2 infection, required intensive oxygen support with a significantly high mortality rate (52.2%). Amongst individuals with severe COVID-19 symptoms, we report a significant decline in the levels of amino acids, notably the branched chains amino acids (BCAAs), more so in the post-TB cohort (FDR <= 0.05) in comparison to mild and asymptomatic cases. Indeed, we identified betaine and BCAAs as potential prognostic metabolic biomarkers of severity and mortality, respectively, in COVID-19 patients who have been exposed to TB. Moreover, we identified serum alanine as an important metabolite at the interface of severity and mortality. Hence, our data associated COVID-19 mortality and morbidity with a long-term metabolically driven consequence of TB infection. In summary, our study provides evidence for a higher mortality rate among COVID-19 infection patients who have history of prior TB infection diagnosis, which mandates validation in larger population cohorts.
Languageen
PublisherFrontiers Media S.A.
Subjectbiomarkers
COVID-19 disease severity
metabolomics
post-tuberculosis long-term consequences
tuberculosis
TitleIdentification of Prognostic Metabolomic Biomarkers at the Interface of Mortality and Morbidity in Pre-Existing TB Cases Infected With SARS-CoV-2
TypeArticle
Volume Number12
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record