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AuthorHoteit, R.
AuthorHoteit, Reem
AuthorYassine, Hadi M.
Available date2022-09-12T16:31:56Z
Publication Date2022-06-01
Publication NameVaccines
Identifierhttp://dx.doi.org/10.3390/vaccines10060919
CitationHoteit, R., & Yassine, H. M. (2022). Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences. Vaccines, 10(6), 919.‏
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85132704289&origin=inward
URIhttp://hdl.handle.net/10576/33887
AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that belongs to the coronavirus family and is the cause of coronavirus disease 2019 (COVID-19). As of May 2022, it had caused more than 500 million infections and more than 6 million deaths worldwide. Several vaccines have been produced and tested over the last two years. The SARS-CoV-2 virus, on the other hand, has mutated over time, resulting in genetic variation in the population of circulating variants during the COVID-19 pandemic. It has also shown immune-evading characteristics, suggesting that vaccinations against these variants could be potentially ineffective. The purpose of this review article is to investigate the key variants of concern (VOCs) and mutations of the virus driving the current pandemic, as well as to explore the transmission rates of SARS-CoV-2 VOCs in relation to epidemiological factors and to compare the virus’s transmission rate to that of prior coronaviruses. We examined and provided key information on SARS-CoV-2 VOCs in this study, including their transmissibility, infectivity rate, disease severity, affinity for angiotensin-converting enzyme 2 (ACE2) receptors, viral load, reproduction number, vaccination effectiveness, and vaccine breakthrough.
Languageen
PublisherMDPI
Subjectclinical consequences
coronavirus disease 2019 (COVID-19)
epidemiological factors
mutations
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants of concern (VOCs)
TitleBiological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences
TypeArticle Review
Issue Number6
Volume Number10
dc.accessType Open Access


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