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AuthorMesmar, J.
AuthorMesmar, Joelle
AuthorFardoun, Manal M.
AuthorAbdallah, Rola
AuthorAl Dhaheri, Yusra
AuthorYassine, Hadi M.
AuthorIratni, Rabah
AuthorBadran, Adnan
AuthorEid, Ali H.
AuthorBaydoun, Elias
Available date2022-09-13T16:24:21Z
Publication Date2021-07-02
Publication NameMolecules
Identifierhttp://dx.doi.org/10.3390/molecules26144295
CitationMesmar, J., Fardoun, M. M., Abdallah, R., Al Dhaheri, Y., Yassine, H. M., Iratni, R., ... & Baydoun, E. (2021). Ziziphus nummularia attenuates the malignant phenotype of human pancreatic cancer cells: Role of ros. Molecules, 26(14), 4295.‏
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85111101682&origin=inward
URIhttp://hdl.handle.net/10576/33929
AbstractPancreatic cancer (PC) is the fourth leading cause of all cancer-related deaths. Despite major improvements in treating PC, low survival rate remains a major challenge, indicating the need for alternative approaches, including herbal medicine. Among medicinal plants is Ziziphus nummu-laria (family Rhamnaceae), which is a thorny shrub rich in bioactive molecules. Leaves of Ziziphus nummularia have been used to treat many pathological conditions, including cancer. However, their effects on human PC are still unknown. Here, we show that the treatment of human pancreatic ductal adenocarcinoma cells (Capan-2) with Ziziphus nummularia ethanolic extract (ZNE) (100–300 µg/mL) attenuated cell proliferation in a time-and concentration-dependent manner. Pretreatment with N-acetylcysteine, an ROS scavenger, attenuated the anti-proliferative effect of ZNE. In addition, ZNE significantly decreased the migratory and invasive capacity of Capan-2 with a concomitant downregulation of integrin α2 and increased cell–cell aggregation. In addition, ZNE inhibited in ovo angiogenesis as well as reduced VEGF and nitric oxide levels. Furthermore, ZNE downregulated the ERK1/2 and NF-κB signaling pathways, which are known to drive tumorigenic and metastatic events. Taken together, our results suggest that ZNE can attenuate the malignant phenotype of Capan-2 by inhibiting hallmarks of PC. Our data also provide evidence for the potential anticancer effect of Ziziphus nummularia, which may represent a new resource of novel anticancer compounds, especially ones that can be utilized for the management of PC.
Languageen
PublisherMDPI AG
SubjectHerbal medicine
Malignant phenotype
Pancreatic cancer
ROS
Ziziphus nummularia
TitleZiziphus nummularia attenuates the malignant phenotype of human pancreatic cancer cells: Role of ros
TypeArticle
Issue Number14
Volume Number26
dc.accessType Open Access


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