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Application of statistical experimental design for optimisation of bioinsecticides production by sporeless Bacillus thuringiensis strain on cheap medium
(2013 , Article)
In order to overproduce bioinsecticides production by a sporeless Bacillus thuringiensis strain, an optimal composition of a cheap medium was defined using a response surface methodology. In a first step, a Plackett-Burman ...
Rhus coriaria L. (Sumac) evokes endothelium-dependent vasorelaxation of rat aorta: Involvement of the cAMP and cGMP pathways
(
Frontiers Media S.A.
, 2018 , Article)
Rhus coriaria L. (sumac) is widely used in traditional remedies and cuisine of countries of the Mediterranean as well as Central and South-West Asia. Administration of sumac to experimental models and patients with diverse ...
Thymus vulgaris (Thyme) inhibits proliferation, adhesion, migration, and invasion of human colorectal cancer cells
(
Mary Ann Liebert Inc.
, 2015 , Article)
Colorectal cancer (CRC) remains one of the most common malignancies and a leading cause of cancer-related deaths. Its prognosis remains poor for patients with several grades of this disease. This underscores the need for ...
Anti-atherosclerotic plants which modulate the phenotype of vascular smooth muscle cells
(
Elsevier
, 2016 , Article)
Background: Cardiovascular disease (CVD) remains the leading cause of global death, with atherosclerosis being a major contributor to this mortality. Several mechanisms are implicated in the pathogenesis of this disease. ...
Salinomycin induces apoptosis and senescence in breast cancer: Upregulation of p21, downregulation of survivin and histone H3 and H4 hyperacetylation
(
Elsevier
, 2013 , Article)
Background
In the present study, we investigated the effect of Salinomycin on the survival of three human breast cancer cell lines MCF-7, T47D and MDA-MB-231 grown in adherent culture conditions.
Methods
Cell viability ...
Mechanisms underlying the antihypertensive effects of garlic bioactives
(
Elsevier Inc.
, 2014 , Article)
Cardiovascular disease remains the leading cause of death worldwide with hypertension being a major contributing factor to cardiovascular disease–associated mortality. On a population level, non-pharmacological approaches, ...
Cyclic AMP-Rap1A signaling mediates cell surface translocation of microvascular smooth muscle α2C-adrenoceptors through the actin-binding protein filamin-2
(
American Physiological Society
, 2013 , Article)
The second messenger cyclic AMP (cAMP) plays a vital role in vascular physiology, including vasodilation of large blood vessels. We recently demonstrated cAMP activation of Epac-Rap1A and RhoA-Rho-associated kinase ...
Cyclic AMP-Rap1A signaling activates RhoA to induce α2c-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells
(
American Physiological Society
, 2012 , Article)
Intracellular signaling by the second messenger cyclic AMP (cAMP) activates the Ras-related small GTPase Rap1 through the guanine exchange factor Epac. This activation leads to effector protein interactions, activation, ...
CAMP induces adhesion of microvascular smooth muscle cells to fibronectin via an epac-mediated but PKA-independent mechanism
(
Cell Physiol Biochem Press
, 2012 , Article)
Background/Aims: Vascular smooth muscle cells (VSMCs) play important roles, both in physiologic and pathophysiologic processes. Adhesion of these cells is critical for their proper functioning, especially in resistance-sized ...
Early stage litter decomposition across biomes
(
Elsevier B.V.
, 2018 , Article)
© 2018 Elsevier B.V. Through litter decomposition enormous amounts of carbon is emitted to the atmosphere. Numerous large-scale decomposition experiments have been conducted focusing on this fundamental soil process in ...