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Mitotic Arrest and Apoptosis in Breast Cancer Cells Induced by Origanum majorana Extract: Upregulation of TNF-α and Downregulation of Survivin and Mutant p53
(
Public Library of Science
, 2013 , Article)
Background: In the present study, we investigated the effect of Origanum majorana ethanolic extract on the survival of the highly proliferative and invasive triple-negative p53 mutant breast cancer cell line MDA-MB-231. ...
Anti-Metastatic and Anti-Tumor Growth Effects of Origanum majorana on Highly Metastatic Human Breast Cancer Cells: Inhibition of NFκB Signaling and Reduction of Nitric Oxide Production
(
Public Library of Science
, 2013 , Article)
Background: We have recently reported that Origanum majorana exhibits anticancer activity by promoting cell cycle arrest and apoptosis of the metastatic MDA-MB-231 breast cancer cell line. Here, we extended our study by ...
Carnosol induces ROS-mediated beclin1-independent autophagy and apoptosis in triple negative breast cancer
(
Public Library of Science
, 2014 , Article)
Background: In this study we investigated the in vitro and in vivo anticancer effect of carnosol, a naturally occurring polyphenol, in triple negative breast cancer.Results: We found that carnosol significantly inhibited ...
Rhus coriaria suppresses angiogenesis, metastasis and tumor growth of breast cancer through inhibition of STAT3, NFκB and nitric oxide pathways
(
Nature Publishing Group
, 2016 , Article)
Recently, we reported that Rhus coriaria exhibits anticancer activities by promoting cell cycle arrest and autophagic cell death of the metastatic triple negative MDA-MB-231 breast cancer cells. Here, we investigated the ...
BRIP1 overexpression is correlated with clinical features and survival outcome of luminal breast cancer subtypes
(
BioScientifica Ltd.
, 2018 , Article)
In Oman, breast cancer is most common, representing approximately more than 25% of all cancers in women. Relatively younger populations of patients (25-40 years) present surprisingly with an aggressive phenotype and advanced ...
Rhus coriaria induces senescence and autophagic cell death in breast cancer cells through a mechanism involving p38 and ERK1/2 activation
(
Nature Publishing Group
, 2015 , Article)
Here, we investigated the anticancer effect of Rhus coriaria on three breast cancer cell lines. We demonstrated that Rhus coriaria ethanolic extract (RCE) inhibits the proliferation of these cell lines in a time- and ...
Novel CD44-downstream signaling pathways mediating breast tumor invasion
(
Ivyspring International Publisher
, 2018 , Article Review)
CD44, also known as homing cell adhesion molecule is a multi-structural cell molecule involved in cell-cell
and cell-extracellular matrix communications. CD44 regulates a number of central signaling pathways,
including ...
Validation of Novel Transcriptional Targets that Underpin CD44-promoted breast cancer cell invasion
(
Qatar University Press
, 2021 , Poster)
Introduction: Breast cancer (BC) is the most common cancer worldwide, and metastasis is its worst aspect and the first cause of death. Metastasis is a multistep process, where an invasion is a recurring event. The process ...
SOD2, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression
(
MDPI
, 2022 , Article Review)
CD44, a cell-adhesion molecule has a dual role in tumor growth and progression; it acts as a tumor suppressor as well as a tumor promoter. In our previous work, we developed a tetracycline-off regulated expression of CD44’s ...
Molecular Evidence of Anticancer Activity of Camel Milk Combined with Camel Urine
(
Austin Publishing Group
, 2021 , Article)
Camel Milk (CM) and Camel Urine (CU) is a traditional practice in the
Middle East and other countries as an alternative treatment against cancer. We
hypothesized that a combination of CM and CU (CM+CU), used at ...