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    Mitotic Arrest and Apoptosis in Breast Cancer Cells Induced by Origanum majorana Extract: Upregulation of TNF-α and Downregulation of Survivin and Mutant p53 

    Al Dhaheri, Yusra; Eid, Ali; AbuQamar, Synan; Attoub, Samir; Khasawneh, Mohammad; Aiche, Ghenima; Hisaindee, Soleiman; Iratni, Rabah... more authors ... less authors ( Public Library of Science , 2013 , Article)
    Background: In the present study, we investigated the effect of Origanum majorana ethanolic extract on the survival of the highly proliferative and invasive triple-negative p53 mutant breast cancer cell line MDA-MB-231. ...
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    Anti-Metastatic and Anti-Tumor Growth Effects of Origanum majorana on Highly Metastatic Human Breast Cancer Cells: Inhibition of NFκB Signaling and Reduction of Nitric Oxide Production 

    Al Dhaheri, Yusra; Attoub, Samir; Arafat, Kholoud; AbuQamar, Synan; Viallet, Jean; Saleh, Alaaeldin; Al Agha, Hala; Eid, Ali; Iratni, Rabah... more authors ... less authors ( Public Library of Science , 2013 , Article)
    Background: We have recently reported that Origanum majorana exhibits anticancer activity by promoting cell cycle arrest and apoptosis of the metastatic MDA-MB-231 breast cancer cell line. Here, we extended our study by ...
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    Carnosol induces ROS-mediated beclin1-independent autophagy and apoptosis in triple negative breast cancer 

    Al Dhaheri, Y.; Attoub, S.; Ramadan, G.; Arafat, K.; Bajbouj, K.; Karuvantevida, N.; AbuQamar, S.; Eid, A.; Iratni, R.... more authors ... less authors ( Public Library of Science , 2014 , Article)
    Background: In this study we investigated the in vitro and in vivo anticancer effect of carnosol, a naturally occurring polyphenol, in triple negative breast cancer.Results: We found that carnosol significantly inhibited ...
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    Rhus coriaria suppresses angiogenesis, metastasis and tumor growth of breast cancer through inhibition of STAT3, NFκB and nitric oxide pathways 

    El Hasasna, Hussain; Saleh, Alaaeldin; Al Samri, Halima; Athamneh, Khawlah; Attoub, Samir; Arafat, Kholoud; Benhalilou, Nehla; Alyan, Sofyan; Viallet, Jean; Al Dhaheri, Yusra; Eid, Ali; Iratni, Rabah... more authors ... less authors ( Nature Publishing Group , 2016 , Article)
    Recently, we reported that Rhus coriaria exhibits anticancer activities by promoting cell cycle arrest and autophagic cell death of the metastatic triple negative MDA-MB-231 breast cancer cells. Here, we investigated the ...
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    BRIP1 overexpression is correlated with clinical features and survival outcome of luminal breast cancer subtypes 

    Gupta I.; Ouhtit A.; Al-Ajmi A.; Rizvi S.G.A.; Al-Riyami H.; Al-Riyami M.; Tamimi Y.... more authors ... less authors ( BioScientifica Ltd. , 2018 , Article)
    In Oman, breast cancer is most common, representing approximately more than 25% of all cancers in women. Relatively younger populations of patients (25-40 years) present surprisingly with an aggressive phenotype and advanced ...
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    Rhus coriaria induces senescence and autophagic cell death in breast cancer cells through a mechanism involving p38 and ERK1/2 activation 

    El Hasasna, Hussain; Athamneh, Khawlah; Al Samri, Halima; Karuvantevida, Noushad; Al Dhaheri, Yusra; Hisaindee, Soleiman; Ramadan, Gaber; Al Tamimi, Nedaa; AbuQamar, Synan; Eid, Ali; Iratni, Rabah... more authors ... less authors ( Nature Publishing Group , 2015 , Article)
    Here, we investigated the anticancer effect of Rhus coriaria on three breast cancer cell lines. We demonstrated that Rhus coriaria ethanolic extract (RCE) inhibits the proliferation of these cell lines in a time- and ...
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    Novel CD44-downstream signaling pathways mediating breast tumor invasion 

    Ouhtit, Allal; Rizeq, Balsam; Abou Saleh, Haissam; Rahman, MD Mizanur; Zayed, Hatem ( Ivyspring International Publisher , 2018 , Article Review)
    CD44, also known as homing cell adhesion molecule is a multi-structural cell molecule involved in cell-cell and cell-extracellular matrix communications. CD44 regulates a number of central signaling pathways, including ...
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    Validation of Novel Transcriptional Targets that Underpin CD44-promoted breast cancer cell invasion 

    Ahmad, Salma; Nazar, Hanan; Alatieh, Nouralhuda; Al-Mansoob, Maryam; Farooq, Zainab; Yusuf, Muna; Ouhtit, Allal... more authors ... less authors ( Qatar University Press , 2021 , Poster)
    Introduction: Breast cancer (BC) is the most common cancer worldwide, and metastasis is its worst aspect and the first cause of death. Metastasis is a multistep process, where an invasion is a recurring event. The process ...
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    SOD2, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression 

    Alateyah, Nouralhuda; Gupta, Ishita; Rusyniak, Radoslaw Stefan; Ouhtit, Allal ( MDPI , 2022 , Article Review)
    CD44, a cell-adhesion molecule has a dual role in tumor growth and progression; it acts as a tumor suppressor as well as a tumor promoter. In our previous work, we developed a tetracycline-off regulated expression of CD44’s ...
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    Molecular Evidence of Anticancer Activity of Camel Milk Combined with Camel Urine 

    Gupta, Ishita; Shanmuganathan, Sumaya; Al-Abri, Hisham; Ouhtit, Allal ( Austin Publishing Group , 2021 , Article)
    Camel Milk (CM) and Camel Urine (CU) is a traditional practice in the Middle East and other countries as an alternative treatment against cancer. We hypothesized that a combination of CM and CU (CM+CU), used at ...
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      Al Dhaheri, Yusra (4) Eid, Ali (4) Iratni, Rabah (4) Ouhtit, Allal (4) ... View More
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      Article (7) Article Review (3) Poster (1)
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