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Cyclic AMP-Rap1A signaling activates RhoA to induce α2c-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells
(
American Physiological Society
, 2012 , Article)
Intracellular signaling by the second messenger cyclic AMP (cAMP) activates the Ras-related small GTPase Rap1 through the guanine exchange factor Epac. This activation leads to effector protein interactions, activation, ...
CAMP induces adhesion of microvascular smooth muscle cells to fibronectin via an epac-mediated but PKA-independent mechanism
(
Cell Physiol Biochem Press
, 2012 , Article)
Background/Aims: Vascular smooth muscle cells (VSMCs) play important roles, both in physiologic and pathophysiologic processes. Adhesion of these cells is critical for their proper functioning, especially in resistance-sized ...