Biological & Environmental Sciences: المرسلات الحديثة
السجلات المعروضة 781 -- 800 من 920
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Colorectal and Prostate Cancer Risk in Diabetes: Metformin, an Actor behind the Scene
( Ivyspring International Publisher , 2014 , Article)Both diabetes and cancer are prevalent diseases whose incidence rates are increasing worldwide, especially in countries that are undergoing rapid industrialization changes. Apparently, lifestyle risk factors including diet, ... -
Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils
( Elsevier , 2015 , Article)Compelling evidence indicates that α-synuclein (α-syn) aggregation plays a central role in the pathogenesis of Parkinson's disease (PD) and other synucleinopathies. Identification of compounds that inhibit or reverse the ... -
A comparison of physiological and transcriptome responses to water deprivation and salt loading in the rat supraoptic nucleus
( American Physiological Society , 2015 , Article)Salt loading (SL) and water deprivation (WD) are experimental challenges that are often used to study the osmotic circuitry of the brain. Central to this circuit is the supraoptic nucleus (SON) of the hypothalamus, which ... -
Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation
( American Society of Hematology , 2015 , Article)Epigenetic events that are essential drivers of lymphocyte transformation remain incompletely characterized. We used models of Epstein-Barr virus (EBV)–induced B-cell transformation to document the relevance of protein ... -
Coffee and its waste repel gravid Aedes albopictus females and inhibit the development of their embryos
( BioMed Central , 2015 , Article)Background Dengue is a prevalent arboviral disease and the development of insecticide resistance among its vectors impedes endeavors to control it. Coffee is drunk by millions of people daily worldwide, which is associated ... -
Biological Activities and Chemical Composition of Methanolic Extracts of Selected Autochthonous Microalgae Strains from the Red Sea
( MDPI AG , 2015 , Article)Four lipid-rich microalgal species from the Red Sea belonging to three different genera (Nannochloris, Picochlorum and Desmochloris), previously isolated as novel biodiesel feedstocks, were bioprospected for high-value, ... -
Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme
( Nature Publishing Group , 2015 , Article)Calcium signalling is important for differentiation-dependent gene expression, but is also involved in other cellular functions. Therefore, mechanisms must exist to distinguish calcium signalling relevant to differentiation. ... -
Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6
( Oxford University Press , 2015 , Article)Jumonji domain-containing protein 6 (JMJD6) is a nuclear protein involved in histone modification, transcription and RNA processing. Although JMJD6 is crucial for tissue development, the link between its molecular functions ... -
Natural Enemies of the Frankliniella Complex Species (Thysanoptera: Thripidae) in Ataulfo Mango Agroecosystems
( Oxford University Press , 2015 , Article)A field survey was conducted in Ataulfo mango (Mangifera indica L.) orchards in Chiapas, Mexico, with the objective of determining the natural enemies of the Frankliniella complex species (Thysanoptera: Thripidae). Seven ... -
IMA Genome-F 4: Draft genome sequences of Chrysoporthe austroafricana, Diplodia scrobiculata, Fusarium nygamai, Leptographium lundbergii, Limonomyces culmigenus, Stagonosporopsis tanaceti, and Thielaviopsis punctulata
( International Mycological Association , 2015 , Article)The genomes of Chrysoporthe austroafricana, Diplodia scrobiculata, Fusarium nygami, Leptographium lundbergii, Limonomyces culmigenus, Stagonosporopsis tanaceti, and Thielaviopsis punctulata are presented in this genome ... -
Rhus coriaria induces senescence and autophagic cell death in breast cancer cells through a mechanism involving p38 and ERK1/2 activation
( Nature Publishing Group , 2015 , Article)Here, we investigated the anticancer effect of Rhus coriaria on three breast cancer cell lines. We demonstrated that Rhus coriaria ethanolic extract (RCE) inhibits the proliferation of these cell lines in a time- and ... -
Collembola at three alpine subarctic sites resistant to twenty years of experimental warming
( Nature Publishing Group , 2015 , Article)This study examined the effects of micro-scale, site and 19 and 21 years of experimental warming on Collembola in three contrasting alpine subarctic plant communities (poor heath, rich meadow, wet meadow). Unexpectedly, ... -
Impacts of different climate change regimes and extreme climatic events on an alpine meadow community
( Nature Publishing Group , 2016 , Article)Climate variability is expected to increase in future but there exist very few experimental studies that apply different warming regimes on plant communities over several years. We studied an alpine meadow community under ... -
Rhus coriaria suppresses angiogenesis, metastasis and tumor growth of breast cancer through inhibition of STAT3, NFκB and nitric oxide pathways
( Nature Publishing Group , 2016 , Article)Recently, we reported that Rhus coriaria exhibits anticancer activities by promoting cell cycle arrest and autophagic cell death of the metastatic triple negative MDA-MB-231 breast cancer cells. Here, we investigated the ... -
Promoter–enhancer looping at the PPARγ2 locus during adipogenic differentiation requires the Prmt5 methyltransferase
( Oxford University Press , 2016 , Article)PPARγ2 is a critical lineage-determining transcription factor that is essential for adipogenic differentiation. Here we report characterization of the three-dimensional structure of the PPARγ2 locus after the onset of ... -
Anti-hypertensive Herbs and their Mechanisms of Action: Part I
( Frontiers Media , 2016 , Article)The use of herbal therapies for treatment and management of cardiovascular diseases (CVDs) is increasing. Plants contain a bounty of phytochemicals that have proven to be protective by reducing the risk of various ailments ... -
Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II
( Frontiers Media , 2016 , Article)Traditional medicine has a history extending back to thousands of years, and during the intervening time, man has identified the healing properties of a very broad range of plants. Globally, the use of herbal therapies to ... -
Inflammogenesis of Secondary Spinal Cord Injury
( Frontiers Media , 2016 , Article)Spinal cord injury (SCI) and spinal infarction lead to neurological complications and eventually to paraplegia or quadriplegia. These extremely debilitating conditions are major contributors to morbidity. Our understanding ... -
Planning for assisted colonization of plants in a warming world
( Nature Publishing Group , 2016 , Article)Assisted colonization is one way of facilitating range shifts for species that are restricted in their ability to move in response to climate change. Here we conceptualize and apply a new decision framework for modelling ... -
Molecular phylogenetic analysis of nuclear genes suggests a Cenozoic over-water dispersal origin for the Cuban solenodon
( Nature Publishing Group , 2016 , Article)The Cuban solenodon (Solenodon cubanus) is one of the most enigmatic mammals and is an extremely rare species with a distribution limited to a small part of the island of Cuba. Despite its rarity, in 2012 seven individuals ...
