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المؤلفNascimento, Denise de Queiroga
المؤلفda Silva, Isaura Isabelle Fonseca Gomes
المؤلفLima, Camilla Albertina Dantas
المؤلفCavalcanti, André de Souza
المؤلفRoberti, Luciana Rodrigues
المؤلفQueiroz, Rosane Gomes de Paula
المؤلفFerriani, Virginia Paes Leme
المؤلفCrovella, Sergio
المؤلفCarvalho, Luciana Martins de
المؤلفSandrin-Garcia, Paula
تاريخ الإتاحة2022-10-24T09:14:52Z
تاريخ النشر2022
اسم المنشورAutoimmunity
المعرّفhttp://dx.doi.org/10.1080/08916934.2022.2128781
الاقتباسDenise de Queiroga Nascimento, Isaura Isabelle Fonseca Gomes da Silva, Camilla Albertina Dantas Lima, André de Souza Cavalcanti, Luciana Rodrigues Roberti, Rosane Gomes de Paula Queiroz, Virginia Paes Leme Ferriani, Sergio Crovella, Luciana Martins de Carvalho & Paula Sandrin-Garcia (2022) Expression of the miR-9-5p, miR-125b-5p and its target gene NFKB1 and TRAF6 in childhood-onset systemic lupus erythematosus (cSLE), Autoimmunity, 55:8, 515-519, DOI: 10.1080/08916934.2022.2128781
الرقم المعياري الدولي للكتاب0891-6934
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85139804239&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/35363
الملخصChildhood- onset systemic lupus erythematosus (cSLE) is a multisystem inflammatory disease that can lead to severe clinical conditions resulting in early comorbidities. Several genetic, environmental, and immunological factors are known to influence the onset of the disease. MiRNAs have been already considered as potential actors involved in the development and activity of the SLE. Thus, understanding the behavior of these regulators can contribute to clarify the inflammatory process affecting SLE patients. Among miRNAs, miR-125b-5p and miR-9-5p targeting NFKB1 and TRAF6 genes can be involved in the etio-pathogenesis of the disease by modulating inflammation. In this study we evaluated miR-9-5p and miR-125b-5p expression and its target genes NFKB1 and TRAF6 in peripheral blood samples (PBMC) from the 35 cSLE patients and 35 healthy controls. MiRNAs and gene target expression have been evaluated by using RT-PCR with specific TaqMan® probes. Both miR-9-5p [Fold Change (FC) = −2.21; p = 0.002] and miR-125b-5p (FC= −3.30; p < 0.0001) and NFKB1 (FC = −1.84; p < 0.001) were downregulated in cSLE patients, while TRAF6 was upregulated (FC = 1.80; p = 0.006) in cSLE patients when compared to controls. A significant correlation was found between miR-125b-5p and its target gene NFKB1 [Spearman (r) = 0.47; p = 0.023]. Our results showed miR-125b-5p and miR-9-5p differential expression in cSLE patients, possibly contributing to better understanding the role of these regulators in cSLE development and disease pathogenesis.
اللغةen
الناشرTaylor and Francis
الموضوعcSLE
gene expression
inflammation
miR-125b
miR-9
العنوانExpression of the miR-9-5p, miR-125b-5p and its target gene NFKB1 and TRAF6 in childhood-onset systemic lupus erythematosus (cSLE)
النوعArticle
الصفحات515-519
رقم العدد8
رقم المجلد55
ESSN1607-842X
dc.accessType Full Text


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