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AuthorDana, Elkhalifa
AuthorRayan, Menatallah
AuthorNegmeldin, Ahmed T.
AuthorElhissi, Abdelbary
AuthorKhalil, Ashraf
Available date2022-10-24T09:23:02Z
Publication Date2022-01
Publication NameBiomedicine & Pharmacotherapy
Identifierhttp://dx.doi.org/10.1016/j.biopha.2021.112385
CitationElkhalifa, D., Rayan, M., Negmeldin, A. T., Elhissi, A., & Khalil, A. (2022). Chemically modified mRNA beyond COVID-19: potential preventive and therapeutic applications for targeting chronic diseases. Biomedicine & Pharmacotherapy, 145, 112385.
ISSN0753-3322
URIhttps://www.sciencedirect.com/science/article/pii/S0753332221011690
URIhttp://hdl.handle.net/10576/35364
AbstractChemically modified mRNA represents a unique, efficient, and straightforward approach to produce a class of biopharmaceutical agents. It has been already approved as a vaccination-based method for targeting SARS-CoV-2 virus. The COVID-19 pandemic has highlighted the prospect of synthetic modified mRNA to efficiently and safely combat various diseases. Recently, various optimization advances have been adopted to overcome the limitations associated with conventional gene therapeutics leading to wide-ranging applications in different disease conditions. This review sheds light on emerging directions of chemically modified mRNAs to prevent and treat widespread chronic diseases, including metabolic disorders, cancer vaccination and immunotherapy, musculoskeletal disorders, respiratory conditions, cardiovascular diseases, and liver diseases.
SponsorQatar University (Grant # QUCG-CPH-20/21-4 and QUCG-CPH-21/22-1)
Languageen
PublisherElsevier
SubjectChemically Modified mRNA
COVID-19
Vaccination
Chronic diseases
Cancer
Diabetes
TitleChemically modified mRNA beyond COVID-19: Potential preventive and therapeutic applications for targeting chronic diseases
TypeArticle Review
Volume Number145
Open Access user License http://creativecommons.org/licenses/by/4.0/
dc.accessType Open Access


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