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AuthorIftikhar, Neelam
AuthorHussain, Abdullah Ijaz
AuthorChatha, Shahzad Ali Shahid
AuthorSultana, Nazia
AuthorRathore, Hassaan Anwer
Available date2022-10-24T10:27:13Z
Publication Date2022-03-01
Publication NameFood Science and Nutrition
Identifierhttp://dx.doi.org/10.1002/fsn3.2695
CitationIftikhar, N., Hussain, A. I., Chatha, S. A. S., Sultana, N., & Rathore, H. A. (2022). Effects of polyphenol- rich traditional herbal teas on obesity and oxidative stress in rats fed a high- fat– sugar diet. Food Science & Nutrition, 10, 698– 711. https://doi.org/10.1002/fsn3.2695
ISSN2048-7177
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85122880645&origin=inward
URIhttp://hdl.handle.net/10576/35390
AbstractHibiscus rosa-sinensis and Zingiber officinalis teas are traditionally used for the therapies of various diseases, including obesity. The present research work was planned to appraise the potential of polyphenol-rich extracts of selected herbal plants in obesity and related biochemical parameters of high-fat–sugar diet-induced obese rats. Three herbal teas were prepared from Hibiscus rosa-sinensis flowers and Zingiber officinalis rhizomes and their mixture (3:1, respectively). Total phenolic contents (TPC) of Hibiscus rosa-sinensis and Zingiber officinalis extracts were found to be 5.82 and 1.45 mg/g of dry plant material, measured as GAE, while total flavonoid contents (TFC) were 9.17 and 1.95 mg/g of dry plant material, measured as CE, respectively. Two doses (250 and 500 mg/kg BW) of each tea were administered and body weight, BMI, kidney, liver, and atherogenic indices, TC, TG, HDL, LDL, VLDL, BT, AST, ALT, AP, SC, MDA, SOD, GSH, and TAC of rats groups were measured. Data showed that higher doses of Hibiscus rosa-sinensis significantly reduced the rat's BMI (0.50 g/cm2) in comparison with the high-fat–sugar diet group (0.79 g/cm2). All treatment groups, especially H-500 group, showed a significant decrease in the elevated kidney and liver weights and atherogenic index in comparison with HFSDC groups. Higher doses of Hibiscus rosa-sinensis significantly decreased the levels of AST, ALT, AP, and SC in comparison with the HFSDC group. A significant decrease in the levels of serum TC, TG, LDL, and VLDL was observed in all the treatment groups in comparison with the HFSDC group. Furthermore, all the teas, especially higher doses of Hibiscus rosa-sinensis, prevented the alterations in MDA, SOD, and GSH levels of experimental groups, thus showing the potential against oxidative stress. It can be concluded from these results that Hibiscus rosa-sinensis teas exhibited strong protective effects against obesity and oxidative stress, especially at higher doses.
Languageen
PublisherJohn Wiley & Sons, Ltd.
SubjectBMI
GSH
high-fat diet
kidney index
LDL and HDL
liver index
MDA
nutraceutical
phenolic acids and flavonoids
SOD
TitleEffects of polyphenol-rich traditional herbal teas on obesity and oxidative stress in rats fed a high-fat–sugar diet
TypeArticle
Pagination698– 711
Issue Number3
Volume Number10
ESSN2048-7177
dc.accessType Open Access


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