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    A Meta-Analysis on Clinical Outcomes of Ceftolozane versus Piperacillin in Combination with Tazobactam in Patients with Complicated Urinary Tract Infections

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    2022_With Wasif_Biomed research International_ Metanalaysis Ceftolozane in UTI.pdf (660.0Kb)
    Date
    2022
    Author
    Saeed, Muhammad Waqas
    Gillani, Syed Wasif
    Mahmood, Rana Kamran
    Vippadapu, Prasanna
    Hussain, Mian Waqar
    Rathore, Hassaan Anwer
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    Abstract
    Objective. To evaluate efficacy and adverse events of ceftolozane/tazobactam in complicated UTI including acute pyelonephritis. Method. Databases that include PubMed, Embase, Scopus, and TRIP were searched. All randomized controlled trials and cohort studies were considered for the study. Statistical analysis was done using a fixed effects model, and results were expressed in proportion for dichotomous data and risk ratio for continuous data with 95% confidence intervals (CI). Results. A clinical cure of ceftolozane/tazobactam was found to be 92% with 95% CI of 90-94 while that of piperacillin/tazobactam was only 78% (95% CI, 74-82) in patients with complicated UTI. Microbiological eradication was still higher in the ceftolozane/tazobactam group (83%, 95% CI 81-88) when compared with piperacillin/tazobactam (63% 95% CI, 58.77-65.2). Ceftolozane/tazobactam was more effective in the treatment of complicated urinary tract infections other than acute pyelonephritis as compared to piperacillin/tazobactam (RR=1.21, 95% CI, 1.07-1.23). Serious adverse events were found comparable in both groups (RR=1.15, 95% CI, 0.64-2.09). Conclusion. The analysis showed that ceftolozane/tazobactam has better clinical outcomes including cure rates and low resistance for the treatment of complicated urinary tract infection.
    URI
    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85136002846&origin=inward
    DOI/handle
    http://dx.doi.org/10.1155/2022/1639114
    http://hdl.handle.net/10576/35397
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    • Pharmacy Research [‎1399‎ items ]

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