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AuthorVippadapu, Prasanna
AuthorGillani, Syed Wasif
AuthorThomas, Dixon
AuthorAhmed, Fiaz
AuthorGulam, Shabaz Mohiuddin
AuthorMahmood, Rana Kamran
AuthorMenon, Vineetha
AuthorAbdi, Semira
AuthorRathore, Hassaan Anwer
Available date2022-10-25T06:41:00Z
Publication Date2022-04
Publication NameFrontiers in Pharmacology
Identifierhttp://dx.doi.org/10.3389/fphar.2022.849044
CitationVippadapu P, Gillani SW, Thomas D, Ahmed F, Gulam SM, Mahmood RK, Menon V, Abdi S and Rathore HA (2022) Choice of Antimicrobials in Surgical Prophylaxis - Overuse and Surgical Site Infection Outcomes from a Tertiary-Level Care Hospital. Front. Pharmacol. 13:849044. doi: 10.3389/fphar.2022.849044
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85128816527&origin=inward
URIhttp://hdl.handle.net/10576/35398
AbstractBackground: This study was aimed to describe the choice of Surgical Antimicrobial Prophylaxis at a tertiary-level care hospital in United Arab Emirates. It also associated the choice between two leading antimicrobials for the SAP to the site of surgery. Methods: A descriptive drug use evaluation was performed retrospectively to study choices of antimicrobials in surgical antibiotic prophylaxis. An analytical cross-sectional study design was used to develop a hypothesis regarding the choice of ceftriaxone. Data were collected from the medical records of Hospital from July 2020 to December 2020. Results were presented in numbers and percentages. Results: SAP data were collected from 199 patients, of which 159 were clean or clean-contaminated. Dirty surgeries (18) needed a higher level of antimicrobials as there were infections to be treated. For other surgeries with no infection, overuse of antimicrobials was found regarding the choice of antimicrobials. Surgical antibiotic Prophylaxis was administered within the recommended time prior to surgeries. Ceftriaxone was preferred over cefuroxime in all types of surgeries based on the timing of Surgical Antibiotic Prophylaxis, wound classification, and the surgical site. A statistically significant association for choice of ceftriaxone over cefuroxime was found regarding surgical sites (p-value <0.05). About 99% of the patients were prescribed discharge antimicrobials when 158 (80%) surgeries were clean or clean-contaminated. Conclusion: Overuse of antimicrobials was found in surgical antimicrobial prophylaxis. Ceftriaxone was preferred more than cefuroxime in all types of surgeries. No surgical site infections were reported. A follow-up comparative study is recommended to decrease antimicrobial use without increasing risk of surgical site infection.
Languageen
PublisherFrontiers Media
Subjectantimicrobial stewardship
cefotaxime
ceftriaxone
surgeries
surgical antimicrobial prophylaxis
surgical site infections
TitleChoice of Antimicrobials in Surgical Prophylaxis - Overuse and Surgical Site Infection Outcomes from a Tertiary-Level Care Hospital
TypeArticle
Pagination1-9
Volume Number13
ESSN1663-9812
dc.accessType Open Access


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