Show simple item record

AuthorShahzadi, Iram
AuthorIslam, Muhammad
AuthorSaeed, Hamid
AuthorHaider, Ali
AuthorShahzadi, Anum
AuthorHaider, Junaid
AuthorAhmed, Nadeem
AuthorUl-Hamid, Anwar
AuthorNabgan, Walid
AuthorIkram, Muhammad
AuthorRathore, Hassaan Anwer
Available date2022-10-26T16:39:56Z
Publication Date2022-11
Publication NameInternational Journal of Biological Macromolecules
Identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2022.08.142
CitationShahzadi, I., Islam, M., Saeed, H., Haider, A., Shahzadi, A., Haider, J., ... & Rathore, H. A. (2022). Formation of biocompatible MgO/cellulose grafted hydrogel for efficient bactericidal and controlled release of doxorubicin. International Journal of Biological Macromolecules, 220, 1277-1286.
ISSN0141-8130
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85137307448&origin=inward
URIhttp://hdl.handle.net/10576/35470
AbstractIn this study, MgO-doped CNC-g-PAA hydrogel was synthesized by grafting poly (acrylic acid) (PAA) onto cellulose nanocrystals (CNC) and then doped Magnesium oxide (MgO) using pH 7.0 and 12.0 to obtain an efficient nanocomposite hydrogel for antibacterial and anti-cancer activities. The synthesized nanocomposite hydrogels were evaluated by detailed characterization and confirmed the formation of a well-interconnected porous structure. MgO/CNC-g-PAA (pH = 12.0) exhibited improved bactericidal tendencies towards gram-negative and gram-positive bacteria, which was further investigated by in-silico molecular docking analyses and also examined the reactive oxygen species production by photocatalysis and free radical-scavenging assay. After this, Doxorubicin (DOX), a model anticancer drug, was successfully loaded into nanocomposites (∼79 %) by electrostatic interaction and confirmed pH-triggered based release, which was over 53.7 % in 24 h. Finally, in vitro cytotoxicity-based analysis confirmed the improved antitumor efficacy of nanocomposite hydrogels. These findings revealed that MgO/CNC-g-PAA hydrogels might be prospective carriers for controlled drug delivery.
SponsorHigher Education Commission (HEC) Pakistan, through NRPU-20-17615 (Muhammad Ikram).
Languageen
PublisherElsevier B.V.
SubjectCellulose nanocrystals (CNC)
Hydrogel
Poly (acrylic acid) (PAA)
TitleFormation of biocompatible MgO/cellulose grafted hydrogel for efficient bactericidal and controlled release of doxorubicin
TypeArticle
Pagination1277-1286
Volume Number220
dc.accessType Full Text


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record