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المؤلفScudiero, I.
المؤلفVito, P.
المؤلفStilo, R.
تاريخ الإتاحة2015-11-05T10:16:08Z
تاريخ النشر2014
اسم المنشورCellular Physiology
المصدرWiley Online library
الاقتباسScudiero, I., Vito, P. and Stilo, R. (2014), The Three CARMA Sisters: So Different, So Similar: A Portrait of the Three CARMA Proteins and Their Involvement in Human Disorders. J. Cell. Physiol., 229: 990–997.
الرقم المعياري الدولي للكتاب1097-4652
معرّف المصادر الموحدhttp://dx.doi.org/10.1002/jcp.24543
معرّف المصادر الموحدhttp://hdl.handle.net/10576/3700
الملخصInitially identified by their ability to modulate the functional activity of BCL10, the three CARMA proteins, CARMA1, -2, and -3, have recently themselves taken a leading role on the stage of molecular medicine. Although considered for some time as simple ancillary proteins, increasingly accumulating recent data evidently indicate a role of primary importance for these three proteins in the pathophysiology of several human tumors and inflammatory disorders. In fact, recent scientific literature clearly establishes that CARMA1 is one of the most mutated genes in a subtype of B-cell lymphoma and, at the same time, responsible for some rare human immunodeficiency conditions. On the other hand, mutations in CARMA2 are responsible for the hereditary transmission of some inflammatory disorders of the skin, including familial psoriasis and ptiriasis; whereas expression of CARMA3 appears to be deregulated in different human tumors. Here we describe and summarize the mutations found in the genes coding for the three CARMA proteins in these different human pathological conditions, and offer an interpretation of the molecular mechanisms from which arise the biological outcomes in which these proteins are involved.
اللغةen
الناشرWiley Periodicals, Inc.
الموضوعCARMA
Human Disorders
العنوانThe Three CARMA Sisters: So Different, So Similar: A Portrait of the Three CARMA Proteins and Their Involvement in Human Disorders
النوعArticle
رقم العدد8
رقم المجلد229
dc.accessType Abstract Only


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