Show simple item record

AuthorAl-Sulaiti, Fatima K.
AuthorNader, Ahmed
AuthorEl-Mekaty, Eman
AuthorElewa, Hazem
AuthorAl-Badriyeh, Daoud
AuthorEl-Zubair, Ahmed
AuthorSaad, Mohamed O.
AuthorAwaisu, Ahmed
Available date2022-12-15T07:16:25Z
Publication Date2020
Publication NameJACCP Journal of the American College of Clinical Pharmacy
ResourceScopus
URIhttp://dx.doi.org/10.1002/jac5.1223
URIhttp://hdl.handle.net/10576/37333
AbstractIntroduction: Vancomycin is commonly used for the treatment of complicated infections caused by methicillin-resistant Staphylococcus aureus. The impact of vancomycin therapeutic drug monitoring (TDM) quality indices on clinical outcomes has not been previously explored. Objectives: This study aims to relate routine vancomycin TDM service quality indices to clinical effectiveness outcomes and to develop a pragmatic vancomycin-specific TDM quality assessment tool that can be used in quality audits. Methods: A retrospective chart review was conducted on adult non-dialysis vancomycin TDM records documented between January 2014 and October 2016 in three tertiary care hospitals under Hamad Medical Corporation (HMC) in Qatar. Evidence-based criteria and pilot-testing were applied to develop a quality assessment tool. The appropriateness of vancomycin TDM service and clinical outcomes were simultaneously evaluated. Results: A 13-criterion vancomycin TDM quality assessment tool was developed and used to evaluate 208 TDM records involving 99 patients. The indications for TDM requests were judged appropriate in 77.4% (n = 161) of the records. However, most of the blood samples were deemed to be incorrectly timed (70.7%, n = 147). Inappropriate vancomycin TDM practices compared with appropriate practices were associated with lower therapeutic cure (47.3% vs 75%, P-value =.009). Conclusions: Vancomycin TDM requests were justified at HMC. However, inappropriate practices were associated with suboptimal clinical outcomes, signifying the importance of routine quality audits using rigorous evaluation tools. The developed tool can be used to determine setting-specific deficiencies in routine vancomycin TDM practices. 2020 Pharmacotherapy Publications, Inc.
SponsorThis study was funded by Qatar University, Student Grant (QUST-CPH-SPR-14/15-12).
Languageen
PublisherBlackwell Publishing Ltd
Subjectanti-bacterial agents
infections
pharmacokinetics
pharmacy
therapeutic drug monitoring
vancomycin
TitleVancomycin therapeutic drug monitoring service quality indices and clinical effectiveness outcomes: A retrospective cohort and clinical audit
TypeArticle
Pagination778-785
Issue Number4
Volume Number3
dc.accessType Abstract Only


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record