Show simple item record

AuthorAl-Ziftawi, Nour Hisham
AuthorAlam, Mohammed Fasihul
AuthorElazzazy, Shereen
AuthorShafie, Asrul Akmal
AuthorHamad, Anas
AuthorMohamed Ibrahim, Mohamed Izham
Available date2023-01-16T07:45:45Z
Publication Date2022-12-28
Publication NameInternational journal of environmental research and public health
Identifierhttp://dx.doi.org/10.3390/ijerph20010512
CitationAl-Ziftawi, N.H.; Alam, M.F.; Elazzazy, S.; Shafie, A.A.; Hamad, A.; Mohamed Ibrahim, M.I. Cost-Effectiveness and Cost-Utility of Palbociclib versus Ribociclib in Women with Stage IV Breast Cancer: A Real-World Data Evaluation. Int. J. Environ. Res. Public Health 2023, 20, 512. https://doi.org/10.3390/ijerph20010512
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85145972957&origin=inward
URIhttp://hdl.handle.net/10576/38437
AbstractPalbociclib and ribociclib are indicated in the first-line treatment of hormonal-receptor-positive HER-2 negative (HR+/HER-2 negative) advanced breast cancer. Despite their clinical benefit, they can increase healthcare expenditure. Yet, there are no comparative pharmacoeconomic evaluations for them in developing countries, the Middle East, or Gulf countries. This study compared the cost-effectiveness of palbociclib and ribociclib in Qatar. A 10-year within-cycle-corrected Markov's model was developed using TreeAge Pro® software. The model consisted of three main health states: progression-free (PFS), progressed-disease (PD), and death. Costs were obtained from the actual hospital settings, transition probabilities were calculated from individual-patient data, and utilities were summarized from the published literature. The incremental cost-effectiveness ratio (ICER) and the incremental cost-utility ratio (ICUR) were calculated and compared to three gross-domestic-products per capita. Deterministic and probabilistic sensitivity analyses were performed. Ribociclib dominated palbociclib in terms of costs, life-years gained, and quality-adjusted life-years gained. The conclusions remained robust in the different cases of the deterministic sensitivity analyses. Taking all combined uncertainties into account, the confidence in the base-case conclusion was approximately 60%. Therefore, in HR+/HER-2 negative stage IV breast cancer patients, the use of ribociclib is considered cost-saving compared to palbociclib.
SponsorThis study was funded by Qatar University, by financial grant #No. QUST-1-CPH-2019-12.
Languageen
PublisherMDPI
Subjectadvanced breast cancer
cost-effectiveness
cost-saving
cost-utility
cyclin-dependent-kinase 4/6 inhibitors
TitleCost-Effectiveness and Cost-Utility of Palbociclib versus Ribociclib in Women with Stage IV Breast Cancer: A Real-World Data Evaluation
TypeArticle
Issue Number1
Volume Number20
ESSN1660-4601
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record