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المؤلفde Azevêdo Silva, Jaqueline
المؤلفde Lima, Camilla Albertina Dantas
المؤلفGuaraná, Werbson Lima
المؤلفBarbosa, Alexandre Domingues
المؤلفFragoso, Thiago Sotero
المؤلفDuarte, Ângela Luzia Branco Pinto
المؤلفCrovella, Sergio
المؤلفSandrin-Garcia, Paula
تاريخ الإتاحة2023-02-07T07:16:55Z
تاريخ النشر2023-02-01
اسم المنشورInternational Journal of Immunogenetics
المعرّفhttp://dx.doi.org/10.1111/iji.12613
الاقتباسde Azevêdo Silva, J., de Lima, C. A. D., Guaraná, W. L., Barbosa, A. D., Fragoso, T. S., Duarte, Â. L. B. P., Crovella, S., & Sandrin-Garcia, P. (2023). Vitamin D receptor gene polymorphisms influence on clinical profile and bone mineral density at different skeletal sites in postmenopausal osteoporotic women. International Journal of Immunogenetics, 00, 1– 7. https://doi.org/10.1111/iji.12613
الرقم المعياري الدولي للكتاب1744-3121
معرّف المصادر الموحدhttp://hdl.handle.net/10576/39696
الملخصBone remodeling is marked by bone synthesis and absorption balance, and any altered dynamic in this process leads to osteoporosis (OP). The interaction of hormonal, environmental and genetic factors regulate bone metabolism. Since vitamin D displays a classic role in bone metabolism regulation, acting through vitamin D receptor (VDR), the genetic variants within VDR were the first ones associated with bone density and remodelling. Therefore, we investigated whether three single nucleotide polymorphisms (SNPs) within VDR were associated with OP differential susceptibility and clinical profile from postmenopausal versus healthy women from Northeast Brazil. Genetic association study enrolling 146 postmenopausal osteoporotic women as the patient group and 95 healthy age-matched women as the control group. We assessed three SNPs within VDR (rs11168268, rs1540339 and rs3890733), considering the clinical profile of all patients. Our results showed an association of rs11168268 G/G genotype with higher bone mineral density (BMD) mean for the total hip (A/A = 0.828 ± 0.09; A/G = 0.081 ± 0.13; G/G = 0.876 ± 0.12, p = .039), and the rs3890733 T/T genotype was associated with increased OP risk in patients below 60 years old (odds ratio [OR] = 5.12, 95% confidence interval [CI ]= 1.13-23.27, p = .012). The rs1540339 T/T genotype was associated with protection for individuals with low melanin deposition when compared to the high melanin deposition group (OR = 0.24, 95%CI = 0.06-0.94, p = .029). Additionally, 61% of patients presented deficient vitamin D serum levels. The SNP rs11168268 G/G was associated with a significantly increased mean total hip BMD in patients OP, highlighting this SNP and its relationship with BMD.
راعي المشروعThis work was funded by the following Brazilian research agencies: CNPq (Conselho Nacional de Pesquisa), CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) and FACEPE (Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco).
اللغةen
الناشرWiley
الموضوعSNP
VDR
osteoporosis
vitamin D
العنوانVitamin D receptor gene polymorphisms influence on clinical profile and bone mineral density at different skeletal sites in postmenopausal osteoporotic women.
النوعArticle
ESSN1744-313X
dc.accessType Full Text


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