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AuthorSaoudi, Mongi
AuthorHsouna, Anis Ben
AuthorTrigui, Mohamed
AuthorJamoussi, Kamel
AuthorJaoua, Samir
AuthorEl Feki, Abdelfattah
Available date2015-12-27T07:41:03Z
Publication Date2012-07
Publication NameToxicology and Industrial Health
CitationSaoudi, M., Hsouna, A. Ben, Trigui, M., Jamoussi, K., Jaoua, S., & Feki, A. El., (2011), "Differential oxidative stress responses to methanol in intraperitoneally exposed rats : ameliorative effects of Opuntia vulgaris fruit extract", Toxicology and Industrial Health, 28(6): 549-559
ISSN0748-2337
URIhttp://dx.doi.org/10.1177/0748233711416949
URIhttp://hdl.handle.net/10576/3989
AbstractMethanol is primarily metabolized by oxidation to formaldehyde and then to formate. These processes are accompanied by formation of superoxide anion and hydrogen peroxide. This article reports data on the effect of methanol-induced oxidative damage in experimental rats and the role of aqueous extract of Opuntia vulgaris fruit extract (OE) to counteract the toxicity induced by methanol. The animals were exposed to methanol at a dose of 2.37 g/kg body weight intraperitoneally for 30 days. OE was found to contain large amounts of polyphenols and carotenoids and significant antioxidant capacities highlighted by scavenging activities for 2,2-diphenyl-l-picrylhydrazyl. The treatment with methanol exhibited a significant increase in serum hepatic and renal biochemical parameters (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, bilirubin, urea, and creatinine). Methanol intoxication significantly increased hepatic and renal lipid peroxidation evaluated by thiobarbituric acid reactive substances in treated rats as compared to controls. However, hepatic and renal antioxidant enzymes namely superoxide dismutase, catalase, and glutathione peroxidase were significantly decreased in methanol-treated animals as compared to controls. The results concluded that treatment with OE prior to methanol intoxication has significant role in protecting animals from methanol-induced hepatic and renal histopathological and oxidative damage.
SponsorMinistry of Higher Education and Scientific Research in Tunisia.
Languageen
PublisherSAGE Publications
SubjectAntioxidant
Opuntia vulgaris
methanol
oxidative damage
Toxicity
Analysis of Variance
Kidney/drug effects
TitleDifferential oxidative stress responses to methanol in intraperitoneally exposed rats: Ameliorative effects of Opuntia vulgaris fruit extract
TypeArticle
Pagination549-559
Issue Number6
Volume Number28
ESSN1477-0393
dc.accessType Abstract Only


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