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المؤلفBen Hsouna, Anis
المؤلفSaoudi, Mongi
المؤلفTrigui, Mohamed
المؤلفJamoussi, Kamel
المؤلفBoudawara, Tahia
المؤلفJaoua, Samir
المؤلفEl Feki, Abdelfattah
تاريخ الإتاحة2015-12-27T09:14:56Z
تاريخ النشر2011-12
اسم المنشورFood and Chemical Toxicology
المعرّفhttp://dx.doi.org/10.1016/j.fct.2011.09.034
الاقتباس"Characterization of bioactive compounds and ameliorative effects of Ceratonia siliqua leaf extract against CCl4 induced hepatic oxidative damage and renal failure in rats", Hsouna, Anis Ben; Saoudi, Mongi; Trigui, Mohamed; Jamoussi, Kamel; Boudawara, Tahia, et al., (2011) Food and Chemical Toxicology vol. 49(12):p. 3183-3191
الرقم المعياري الدولي للكتاب0278-6915
معرّف المصادر الموحدhttp://hdl.handle.net/10576/3992
الملخصCeratonia siliqua is a typical Mediterranean plant, mainly used in food and Tunisian traditional folk medicine. Among the tested extracts, the ethyl acetate fraction (EACs) exhibited the highest total phenolic and flavonoids content. The antioxidant activity in vitro systems showed a more significant potent free radical scavenging activity of this extract than other analysis fractions. The HPLC finger print of EACs active extract showed the presence of six phenolic compounds. The in vivo results showed that oral administration of CCl4 enhanced levels of hepatic and renal markers (ALT, AST, ALP, LDH, γ-GT, urea and creatinine) in the serum of experimental animals. It also increased the oxidative stress markers resulting in increased levels of the lipid peroxidation with a concomitant decrease in the levels of enzymatic antioxidants (SOD, CAT, GPx) in both liver and kidney. The pre-treatment of experimental rats with 250 mg/kg (BW) of the EACs, by intraperitoneal injection for 8 days, prevented CCl4 induced disorders in the levels of hepatic and kidney markers. The biochemical changes were in accordance with histopathological observations suggesting a marked hepatoprotective and nephroprotective effect of the EACs extract.
راعي المشروعTunisian “Ministry of Higher Education, Scientific Research and Technology”
اللغةen
الناشرElsevier Ltd
الموضوعPhenolic compounds
Protective effect
Oxidative stress
Carbon tetrachloride
Drug-Induced Liver Injury/pathology
Flavonoids/pharmacology
Lipid Peroxidation/drug effects
Alanine Transaminase/blood
العنوانCharacterization of bioactive compounds and ameliorative effects of Ceratonia siliqua leaf extract against CCl4 induced hepatic oxidative damage and renal failure in rats
النوعArticle
الصفحات3183-3191
رقم العدد12
رقم المجلد49
ESSN1873-6351
dc.accessType Abstract Only


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