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المؤلفAl-Mansoob, Maryam
المؤلفAhmad, Salma M. S.
المؤلفOuhtit, Allal
تاريخ الإتاحة2023-02-13T10:51:13Z
تاريخ النشر2022
اسم المنشورFrontiers in Oncology
المصدرScopus
معرّف المصادر الموحدhttp://dx.doi.org/10.3389/fonc.2022.878034
معرّف المصادر الموحدhttp://hdl.handle.net/10576/40018
الملخصBreast Cancer (BC) is the most common and the major health issue in women worldwide. Metastasis, a multistep process, is the worst aspect of cancer and tumor cell invasion is the defining step. Tumor cell invasion requires cell adhesion molecules (CAMs), and alterations in CAMs is considered as an initiating event in metastasis. Among CAMs, CD44 is a large family of more than 100 isoform, and its precise function was initially controversial in BC. Therefore, we have previously established a (Tet)-off inducible expression system of CD44 in MCF-7 primary BC cell line, and showed that CD44 promoted BC invasion/metastasis both in vitro and in vivo. A microarray gene expression profiling revealed more than 200 CD44-downstream potential transcriptional target genes, mediating its role in BC cell invasion and metastasis. Among these CD44-target genes, the Pre-mRNA cleavage complex 2 protein (PCF11) was upregulated upon the activation of CD44 by its major ligand hyaluronan (HA); This prompted us to hypothesize PCF11 as a potential novel transcriptional target of CD44-promoted BC cell invasion and metastasis. A large body of evidence from the literature supports our hypothesis that CD44 might regulate PCF11 via MAPK/ERK pathway. This review aims to discuss these findings from the literature that support our hypothesis, and further provide possible mechanisms linking CD44-promoted cell invasion through regulation of its potential target PCF11. Copyright 2022 Al-Mansoob, Ahmad and Ouhtit.
راعي المشروعQatar Foundation: Association of Pathology Chairs: Qatar UniversityQatar University Internal grant number funded this research: QUST-1-CAS2019-22, QUST-2-CAS-2022-486 QUST-2-CAS-2022-487 Qatar Foundation grant number: UREP24-117-1-027 and APC. The Qatar National Library provided open Access funding.
اللغةen
الناشرFrontiers Media S.A.
الموضوعbreast cancer
CD44
hyaluronan
metastasis
PCF11
العنوانPCF11, a Novel CD44-Downstream Transcriptional Target, Linking Its 3'-End Polyadenylation Function to Tumor Cell Metastasis
النوعArticle Review
رقم المجلد12
dc.accessType Open Access


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