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AuthorFarooq, M.
AuthorTaha, N.A.
AuthorButorac, R.R.
AuthorEvans, D.A.
AuthorElzatahry, A.A.
AuthorElsayed, E.A.
AuthorWadaan, M.A.M.
AuthorAl-Deyab, S.S.
AuthorCowley, A.H.
Available date2015-12-29T12:54:36Z
Publication Date2015-10
Publication NameInternational Journal of Molecular Sciences
ResourceScopus
CitationFarooq M., Taha N.A., Butorac R.R., Evans D.A., Elzatahry A.A., Elsayed E.A., Wadaan M.A.M., Al-Deyab S.S., Cowley A.H., Biological screening of newly synthesized BIAN N-heterocyclic gold carbene complexes in zebrafish embryos, (2015) International Journal of Molecular Sciences, 16 (10), pp. 24718-24731.
ISSN1422-0067
URIhttp://dx.doi.org/10.3390/ijms161024718
URIhttp://hdl.handle.net/10576/4017
AbstractN-Heterocyclic carbene (NHC) metal complexes possess diverse biological activities but have yet to be extensively explored as potential chemotherapeutic agents. We have previously reported the synthesis of a new class of NHC metal complexes N-Heterocyclic with acetate [IPr(BIAN)AuOAc] and chloride [IPr(BIAN)AuCl] ligands. In the experiments reported herein, the zebrafish embryos were exposed to serial dilutions of each of these complexes for 10-12 h. One hundred percent mortality was observed at concentrations ?50 ?M. At sub-lethal concentrations (10-30 ?M), both compounds influenced zebrafish embryonic development. However, quite diverse categories of abnormalities were found in exposed embryos with each compound. Severe brain deformation and notochord degeneration were evident in the case of [IPr(BIAN)AuOAc]. The zebrafish embryos treated with [IPr(BIAN)AuCl] exhibited stunted growth and consequently had smaller body sizes. A depletion of 30%-40% glutathione was detected in the treated embryos, which could account for one of the possible mechanism of neurotoxicity. The fact that these compounds are capable of both affecting the growth and also compromising antioxidant systems by elevating intracellular ROS production implies that they could play an important role as a new breed of therapeutic molecules.
SponsorDeanship of Scientific Research at King Saud University for funding this research group No. RGP-284 and Robert A. Welch Foundation (Grant F-0003).
Languageen
PublisherMDPI AG
SubjectBIAN
SubjectN-heterocyclic carbenes complexes
SubjectNeurotoxicity
SubjectOxidative stress
SubjectZebrafish
TitleBiological screening of newly synthesized BIAN N-heterocyclic gold carbene complexes in zebrafish embryos
TypeArticle
Pagination24718-24731
Issue Number10
Volume Number16


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