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AuthorLeandro, Dalila Bernardes
AuthorCelerino da Silva, Ronaldo
AuthorRodrigues, Jessyca Kalynne Farias
AuthorLeite, Maria Carollayne Gonçalves
AuthorArraes, Luiz Claudio
AuthorCoelho, Antonio Victor Campos
AuthorCrovella, Sergio
AuthorZupin, Luisa
AuthorGuimarães, Rafael Lima
Available date2023-03-12T06:07:40Z
Publication Date2023-02-01
Publication NameLife
Identifierhttp://dx.doi.org/10.3390/life13020397
CitationLeandro, D.B.; Celerino da Silva, R.; Rodrigues, J.K.F.; Leite, M.C.G.; Arraes, L.C.; Coelho, A.V.C.; Crovella, S.; Zupin, L.; Guimarães, R.L. Clinical–Epidemiological Characteristics and IFITM-3 (rs12252) Variant Involvement in HIV-1 Mother-to-Children Transmission Susceptibility in a Brazilian Population. Life 2023, 13, 397. https://doi.org/10.3390/life13020397
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85148960416&origin=inward
URIhttp://hdl.handle.net/10576/40925
AbstractMother-to-children transmission (MTCT) is the main infection route for HIV-1 in children, and may occur during pregnancy, delivery, and/or postpartum. It is a multifactorial phenomenon, where genetic variants play an important role. This study aims at analyzing the influence of clinical epidemiological characteristics and a variant (rs12252) in interferon-induced transmembrane protein 3 (IFITM-3), a gene encoding an important viral restriction factor, on the susceptibility to HIV-1 mother-to-children transmission (MTCT). A case–control study was performed on 209 HIV-1-infected mothers and their exposed infected (87) and uninfected (122) children from Pernambuco, Brazil. Clinical–epidemiological characteristics are significantly associated with MTCT susceptibility. Transmitter mothers have a significantly lower age at delivery, late diagnosis, deficiency in ART use (pregnancy and delivery), and detectable viral load in the third trimester of pregnancy compared with non-transmitter mothers. Infected children show late diagnosis, vaginal delivery frequency, and tend to breastfeed, differing significantly from uninfected children. The IFITM-3 rs12252-C allele and TC/CC genotypes (dominant model) are significantly more frequent among infected than uninfected children, but the statistical significance does not remain when adjusted for clinical factors. No significant differences are observed between transmitter and non-transmitter mothers in relation to the IFITM-3 variant.
SponsorThis research was funded by Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco–FACEPE (grant numbers APQ-0599-2.02/14, APQ-0077-2.02/17 and BCT-0081-2.02/17), Programa Nacional de Pós-doutoramento–PNPD–Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (grant number 88882.306352/2018-01), and IRCCS Burlo Garofolo/Italian Ministry of Health (RC47/20).
Languageen
PublisherMDPI
Subjectclinical epidemiological factors
HIV-1
IFITM-3
mother-to-children transmission
viral restriction factor
TitleClinical–Epidemiological Characteristics and IFITM-3 (rs12252) Variant Involvement in HIV-1 Mother-to-Children Transmission Susceptibility in a Brazilian Population
TypeArticle
Issue Number2
Volume Number13
ESSN2075-1729
dc.accessType Open Access


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