PREPARATION AND CHARACTERIZATION OF NANOSTRUCTURE MATERIAL FOR BIOLOGICAL APPLICATION
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Currently, nanomaterial has gained much attention in medical applications. Two different nanostructured materials were synthesized for biomedical purposes in this approach. Firstly, a composite of bimetallic nanoparticles containing Ag and Ni supported on metal oxide (TiO2) was successfully fabricated by co-precipitation manner via NaBH4 as a strong reducing agent employed as a photocatalyst and disinfector. A 1 g/L of NiO/Ag/TiO2 nanocomposite was assessed towards the decomposition of dyes (Methylene blue (MB)), Aspirin, and Paracetamol as pharmaceutical waste with a reduction rate of (93.19%, 77%, and 68.4%, respectively) under visible light within 60 minutes. Furthermore, the effect of annealing was studied which represents a faster degradation of MB dye and higher efficiency reaching 95.92% under visible light within 60 minutes. The basic mechanism of the photodegradation of MB via NiO/Ag/TiO2 nanocomposite was outlined. In addition, even after three cycles, the catalyst showed a significant degrading efficiency reached 90.4%. Next, the nanoparticle was evaluated against two different strains of bacteria (E. coli and Staphylococcus aureus.) in both visible light and dark conditions. The composite shows a dose-dependent bacteriostatic in both bacteria and has a bactericidal effect on E. coli that are exposed to 1 g/L of the material. Second, the preparation of virus-like silica mesoporous nanoparticles (V-MSN) as a drug carrier was done in this work. Due to their biomedical application, it is essential to find the in-vivo model toxicity of this medical carrier. However, the drug has been found to be non-hazard for doses up to 1000 mg/L tested on the zebrafish embryos model.
- Materials Science & Technology [50 items ]